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Effects of Poria Combined with Aerobic Exercise on the Expression of ICAM-1, LFA-1 and TF in Aortic Arch Wall and Blood Lipid of Rats

Author: LiZuo
Tutor: RenJianSheng
School: Wuhan Institute of Physical Education
Course: Human Movement Science
Keywords: Poria Aerobic exercise Atherosclerosis Adhesion molecule ICAM-1 LFA-1 TF
CLC: R285
Type: Master's thesis
Year: 2009
Downloads: 73
Quote: 1
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Abstract


Objective: To investigate the the Poria preventive effect on arterial atherosclerosis with aerobic exercise and explore its possible mechanism to provide a theoretical basis for the development of new atherosclerosis prevention methods. Method: 1. Grouping of experimental animals and modeling: 60 12-week-old male Sprague-Dawley rats were randomly divided into control group (C group), high fat diet group (HC group), drug group (M), saline group (SC group) and joint intervention group (ME group). Blank group (C) with a normal diet, the rest of the group were treated with 600 000 IU / kg Vitamin D3 intraperitoneal injection combined with a high fat diet atherosclerosis model. The modeling of the animals in each group are 10 weeks. Modeling during the M group, SC group and ME group were given 15g crude drug / kg in? D Poria decoction orally with the drug equal amount of normal saline and Poria decoction orally combined 6 times a week, each 1 hours without load swimming motion to intervene. After all rats modeling disposable drawn. Immunohistochemical determination of aortic arch wall ICAM-1 test indicators and methods: HE and Weigert's elastic fiber staining the wall of the aortic arch morphology changes; Enzymatic determination of serum TG, LDL-C, HDL-C levels; , LFA-1 and TF expression, the expression level of the integrated optical density (IOD). All data used SPSS16.0 for statistical analysis. Results: 1. Lipid levels: ME group LDL-C levels, TG levels were 1.39 ± 0.41,0.72 ± 0.08, the rate of increase was significantly lower than the HC group (3.17 ± 0.86,1.71 ± 0.38), the SC group (3.21 ± 0.63, 1.63 ± 0.47) (P lt; 0.01) and M group (1.73 ± 0.21,0.87 ± 0.16) (P lt; 0.05); the ME group HDL-C level of 1.21 ± 0.29, significantly higher than the other groups (P lt; 0.05). 2. ICAM-1, TF expression levels: the ME groups ICAM-1, TF immunohistochemistry integrated optical density values ??were 4.01 ± 2.61,1.01 ± 0.25, expression levels significantly lower than the HC group (18.26 ± 6.26,21.34), SC group (18.71 ± 5.57,19.46 ± 7.21) (P lt; 0.01) and M group (6.83 ± 3.07,3.27 ± 1.36) (P lt; 0.05). 3. LFA-1 expression levels: ME group and M group LFA-1 immunohistochemistry integral optical density values ??were 2.86 ± 0.45,3.30 ± 0.86, were significantly lower than the HC group (14.26 ± 4.24) and the SC group (13.71 ± 6.33 ) (P LT; 0.01), between the ME group and the group M no significant differences. Conclusion: The 1. Tuckahoe with aerobic exercise can effectively suppress elevated cholesterol fed rat serum LDL-C and TG levels and to increase HDL-C levels. 2. Poria with aerobic exercise can significantly inhibit ICAM-1, and the abnormal expression of LFA-1 and TF on the high-fat diet in rat aortic arch wall. With aerobic exercise and Poria Poria unilateral intervention atherosclerosis in rats may be on the high-fat diet-induced atherosclerosis delaying the joint role better than Poria single role.

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