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Isolation and Structure Elucidation of Alkaloids from Dactylicapnos Scandens (D.Don) Hutch.

Author: WangFuHua
Tutor: ChenHaiLin;HouAiJun
School: Fudan University
Course: Medicinal Chemistry
Keywords: Dactylicapnos Dactylicapnos case Papaveraceae The apo Philippine alkaloids Of Pronto category alkaloids
CLC: R284
Type: Master's thesis
Year: 2009
Downloads: 197
Quote: 0
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Abstract


The Papaveraceae Zijin dragon species Dactylicapnos , (Dactylicapnos scandens (D.Don) Hutch.) Also known as string sticks lotus , peas VII , River Hill seven mainly distributed in Yunnan , Sichuan , Guangxi , Tibet , its root is used analgesic, hemostatic , anti-inflammatory , the effect of antihypertensive treat a variety of pain , is China 's Yunnan Bai traditional conventional Chinese herbal medicine . Some scholars study its chemical composition , isolated from apo Fe the alkaloids and Pronto category alkaloids , and the analgesic effect and mechanism of total alkaloid extracted from the preliminary study , description of alkaloids the main active ingredient Dactylicapnos . However , apart from a few reports , domestic and outside of its chemical composition were not in-depth study on the chemical composition of this plant research . So far, the number of alkaloids found not many . In further understanding Dactylicapnos Alkaloids , our research group Alkaloids of Dactylicapnos contained . Total alkaloid extract of the plant root separation and purification, and spectroscopic structural identification of eight monomer compounds , they were identified as the d - isocorydine D ( d - isocorydine , 1 ) the dispatched product ( protopine , 2 ) , the the d - magnolia alkali ( the d - magnoflorine 3 ) , D - iso- purple pansy butoxy -beta -N - oxide ( d - isocorydine -beta -N -oxide , 4 ) , d - CORYDALIS butoxy - α - N - oxide ( d - corydine -alpha -N -oxide , 5 ) , the the d - CORYDALIS butoxy - β - N - oxide ( d - corydine -beta -N - oxide, 6 ) 6S, 6aS - N -methyl- six barge alkali (6S , 6aS -N - methyllaurotetanine -alpha -N -oxide , 7 ) , 6R, 6aS - N -methyl- 6 barge alkali ( 6R , 6aS -N - methyllaurotetanine - β-N-oxide, 8). Among them, the compounds 4 to 8 obtained from this plant for the first time , is also a class of oxidative the apo Philippines alkaloid first isolated from the genus . Finally, the genus Dactylicapnos chemical composition and pharmacological studies reviewed .

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical
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