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Intervention on the Treatment of Elderly Patients with Advanced Non-small Cell Lung Cancer Radiotherapy and Chemotherapy Tolerance

Author: DingJingYong
Tutor: ShiHengJun;LiangJun
School: Fourth Military Medical University
Course: Traditional Chinese Medicine
Keywords: Differential Treatment Chemotherapy Radiotherapy Taxotere Non - small cell lung cancer Tolerated Elderly patients
CLC: R273
Type: Master's thesis
Year: 2009
Downloads: 99
Quote: 0
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Abstract


Purpose of lung cancer incidence continues to increase, the major diseases that endanger human life and health, the incidence of lung cancer mortality accounted cancer in men a women 2 to 3, has a similar incidence of Chinese cities and international trend, rural incidence of lung cancer is gradually increased. Which accounted for 70% to 80% of the number of lung cancer cases NSCLC treatment when only 15% of patients were able to surgical treatment, most patients have Ⅲ, Ⅳ stage, lost the chance of operation. Evidence-based medicine that chemotherapy is the preferred treatment for advanced lung cancer. The clinical efficacy confirmed that radiation therapy is also important to one of the treatment of advanced NSCLC. Malignancy is a systemic disease, with a particular treatment alone may lead to failure. The oncologist put forward the concept of comprehensive treatment, by a large number of clinical practice, the majority of the international oncology community agree that the effects of comprehensive treatment is superior to monotherapy in tumors. Synchronous chemoradiotherapy synergistic anticancer effects can increase the intensity of the treatment of the tumor has become in recent years one of the hot. Elderly patients with a variety of physiological hypofunction, poor tolerance of chemotherapy drugs and radiation, synchronous chemoradiotherapy in increased tumor treatment intensity at the same time, it also brings the increase in treatment-related toxicity, affecting the patient's quality of life. Cancer has been defined as a \Chinese medicine syndrome differentiation in the human body as a whole regulation, prevention has a significant advantage to put the side effects of chemotherapy, so the study in which, and the extent to which improve the patients tolerated chemoradiotherapy has important significance to improve the quality of life. The purpose of this project is to modern clinical research, with the International Quality of Life Scale, KPS and ECOG performance status, the TCM symptom scale observation concurrent chemoradiotherapy tolerance evaluation of diagnosis and treatment intervention for elderly patients with advanced non-small cell lung cancer. Methods and Results 20 cases III IV elderly NSCLC patients according to whether or not to accept Chinese medicine diagnosis and treatment is divided into two groups, the study group (10 cases), the control group (10 cases) only accept Chinese medicine syndrome and concurrent chemoradiotherapy concurrent chemoradiotherapy, two groups was no statistical difference between age and gender, using EORTCQLQ C30, KPS score, ECOG score, TCM Syndrome Scale as efficacy evaluation tools, before and after evaluation of the intervention. Results: the quality of life in all areas of the study group score improved significantly after treatment, the control group decreased between the two sets of difference scores between the difference was significant (P lt; 0.05); KPS, ECOG the TCM symptom scale scores showed similar results. Qi phlegm heat in the diagnosis and treatment, Qi phlegm type, qi stagnation is mainly syndrome type. All patients in eight principal syndromes Youyi Qi, Yin up, Visceral Syndrome lung deficiency, spleen more. The long-term effect is observed. Conclusion TCM syndrome theory with elderly patients with advanced non-small cell lung cancer concurrent chemoradiotherapy can improve the quality of life of patients and improve tolerability. In the treatment of advanced lung cancer, it is recommended to Yiqiyangyin, tune up the stomach is the most basic treatment principle to increasing and improving the quality of life in patients with purpose.

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