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The Change of Cell Cycle and Proliferation after and Before on Locally Advanced Cervical Cancer of Neoadjuvant Chemotherapy and Studying the Value of Prediction Chemotherapeutical Sensitivity

Author: YangHongWen
Tutor: ChenZhongDong
School: Nanhua University
Course: Oncology
Keywords: Cervical cancer Neoadjuvant chemotherapy Cell Cycle PCNA Evaluation
CLC: R737.33
Type: Master's thesis
Year: 2008
Downloads: 131
Quote: 0
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Abstract


Objective: to investigate neoadjuvant chemotherapy ( naCt ) for locally advanced cervical carcinoma cell cycle , proliferation and apoptosis of cervical cancer each phase of cell ratio and proliferating cell nuclear antigen (PCNA) as indicators Sensitivity evaluation and short-term efficacy of neoadjuvant chemotherapy determination viable sex . Methods: 49 patients with locally advanced cervical cancer neoadjuvant chemotherapy clinical data collection neoadjuvant chemotherapy before biopsy and intraoperative specimens organizations , locally advanced cervical cancer before and after neoadjuvant chemotherapy tumor cell cycle distribution by flow cytometry analysis and use immunohistochemical detection of proliferating cell nuclear antigen expression . Results: 49 patients with locally advanced cervical cancer patients with neoadjuvant chemotherapy treatment after 2 weeks to evaluate the clinical efficacy , clinically effective ( CR PR ) was 79.6% (39/ 49 ) , surgery after neoadjuvant chemotherapy was 85.7% (42 / 49 ) . Neoadjuvant chemotherapy before cell cycle distribution mainly to cells in G0/G1 phase ( 62.71 % ± 11.31 % ) , the ratio of G0/G1 of cells up to 83.5% after neoadjuvant chemotherapy is reflected in the G0/G1 phase cells decreased G2 / M phase cells significantly increased apoptosis rate increased , significant difference ( P lt ; 0.05 ) before and after chemotherapy . Neoadjuvant chemotherapy the effective group S - phase fraction ( SPF ) was significantly higher than neoadjuvant chemotherapy ineffective group , significant difference between ( 21.47 ± 5.21VS9.63 ± 2.58 , P lt ; 0.05 ) Neoadjuvant chemotherapy group effective chemotherapy before cervical cancer tissue proliferation index of PCNA was significantly higher than ineffective group ( P lt ; 0.05 ) Conclusion: neoadjuvant chemotherapy can reduce the local tumor , improve parametrial infiltration , reduce tumor stage , is conducive to improve the quality of the surgical treatment of locally advanced cervical cancer . Cisplatin-based neoadjuvant chemotherapy by changing locally advanced cervical cancer cell cycle kinetics, inhibition of tumor cell proliferation and induce apoptosis of tumor cells to chemotherapy generated response to kill tumor cells . Neoadjuvant chemotherapy prior to S phase cell ratio and PCNA proliferation index is an important indicator to determine locally advanced cervical cancer chemosensitivity and short-term effect .

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Uterine tumors
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