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The Expression and Significanic of Invasion Dendritic Cells and Vascular Endothelial Growth Factor in Human Breast Carcinoma

Author: SongYongWei
Tutor: WangZhongYu
School: Dalian Medical University
Course: General Surgery
Keywords: breast carcinoma dendritic cell VEGF
CLC: R737.9
Type: Master's thesis
Year: 2009
Downloads: 70
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Abstract


Objective: To investigate the dendritic cells and VEGF changes in human breast cancer and in tumor surrounding normal tissues,how the cell changes in quality and quantity in different conditions,such as different grades,different size of tumors,positive or negative of metastases of axillary lymph nodes,and different ER,PR expression, and the relationship between the infiltration and maturation of dendritic cells and VEGF.Methods:1.Samples and HE dyeing:the tumors and tumor surrounding normal tissues were prepared form our clinical patients,the samples were preserved in minus 80 celsius degree in 30 min after they were resected in operations, then the samples were paraffined,slice up into 3μm.Again pathological diagnoses of each sample and its invasive depth were conformed after HE dyeing,but before the immunohistochemistry as say.2.Immunohistochemistry detection of dendritic cells’phenotype in the infiltrating duct carcinoma and tumor srrounding normal tissues of 61 patients:the express of dendritic cells and VEGF were detected in the tumors and tumor surrounding normal tissues.Results:1.Tumor size and VEGF were related closely(p<0.05).VEGF were also different in I,II,III grade of diseases(p<0.05).VEGF in breast carcinoma did not relate to age, menstruation, axillary lymph nodes metastases, and ER,PR,or HER-2.2 Expression rate of V EGF in tumor were 75.41%, tumor surrounding normal tissues while expression rate of VEGF were 22.95%, all above difference was statistically significant(P<0.05)3 The quantity of invasive dendritic cells were not realted to ER ,PR or HER-2,and related to clinical grades.4 The expression of CD1a and CD83 positive cells in tumors and tumor surrounding normal tissues was statistically significant(P<0.05). The quan- tity of dendritic cells was less in tumor.5CD1a positive cells was not statistically significant(P<0.05)between the group of VEGF positive and the one of VEGF negative.CD83 positive cells was statistically significant(P<0.05)between the group of VEGF posi- tive and the one of VEGF negative.Conclusion:1.The expression of VEGF was low in benign tumor,but high in breast carcinoma.2.The quantity of CD1a and CD83 dendritic cells was decreased obviously in breast carcinoma.It was obviously negatively correlated with the immunological function3.The quantity of dendritic cells was decreased obviously in breast carcinoma, dendritic cells as a signal of neoplasm metastasis and clinical characteristics of breast cacinoma,which can bolt the high risk patients.4. CD83 dendritic cells was related with VEGF.VEGF may inhabit the mature of dendritic cell.

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Breast tumor
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