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Objective: detection of coronary artery disease in patients with percutaneous coronary interventional therapy (percutaneous coronary intervention, PCI) dynamic changes within 12h after preoperative serum OPG (osteoprotegerin, OPG), and high-sensitivity C-reactive protein (high- sensitivity C-reactive protein, hs-CRP), troponin T (cardiac troponin T, CTnT) compared to the prognosis of OPG predictive value of acute coronary syndrome (acute coronary syndrome, ACS) and PCI ; rated the surgery during revascularization may cause myocardial injury. : Filter out of the 50 patients in our hospital underwent PCI in patients with coronary heart disease included in the study, divided into acute coronary syndrome (Acute Coronary Syndrome, ACS) PCI group (n = 20 patients) and stable angina pectoris (Stable Angina Pectoris, SAP) PCI group (n = 30 patients). 20 patients underwent coronary angiography (coronary arteriography, CAG) and set the normal control group. Measured by ELISA in each group of patients in the preoperative and postoperative 1h and 12h serum OPG, hs-CRP and CTnT concentration. Patients undergoing PCI surgery, intraoperative detailed record of the total time, the total pressure of the balloon dilatation, the expansion frequency, and the number of implanted stents, the correlation between the differences between each index in each group was compared results. Successful intervention (PCI) treatment in patients with clinical follow-up of 6 months were observed major adverse cardiac events (major adverse cardiac events, MACE) occurred in the patients in each group. Results: 1.ACS group, SAP group and control group preoperative level of each index comparison: the ACS group OPG, hs-CRP and CTnT levels significantly compared with the SAP group and control group increased (P lt; 0.01); SAP group OPG , hs-CRP compared with the control group was significantly higher (P lt; 0.01), but the difference was not statistically significant CTnT level compared with the control group. Level of each indicator 2.ACS group before and after surgery, and SAP group comparison: the two PCI Patients 1h of OPG, with no significant difference in the level of hs-CRP and CTnT preoperative 12h than before surgery, but after surgery were significantly elevated (P lt; 0.05). Each index in the control group showed no significant difference before and after surgery. 3. OPG elevated the total pressure balloon dilatation and surgery, total time, and the expansion of the number of times was a positive correlation (P is for 0.001,0.001,0.007). The 4. OPG and hs-CRP and CTnT was positively correlated (P lt; 0.001). Follow-up results: the follow-up period 5 patients of MACE, including myocardial infarction, recurrent angina two cases, again PCI1 cases, 1 death. The five cases MACE ACS Group 4 cases, SAP group 1 patients. MACE occurred in the preoperative of OPG, hs-CRP levels were significantly elevated cases. Conclusion: 1.OPG are valuable predictors of ACS. 2. Reduce PCI, balloon dilation total pressure, total time, and the expansion of the number of times may reduce intraoperative myocardial injury. 3.OPG may be a risk factor for occurrence of MACE in patients after PCI.
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