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Objective To study the MDR1, p53 and VEGF expression in gastric carcinoma explore the relationship between the three express its relationship with tumor invasion, metastasis and prognosis. Methods Handan city hospital in January 2004 -2006 in January between radical surgery, pathology and clinical follow-up data complete with gastric cancer, 80 cases were detected by immunohistochemistry and gastric cancer tissue MDR1, p53 and VEGF expression, and clinical follow-up data, application software SPSS17.0 analysis gastric MDR1, p53 and VEGF expression and its relationship with the relationship between gastric cancer invasion, metastasis and prognosis. Results (1) MDR1 in gastric cancer positive expression rate was 76.25%, in 20 cases in the control group, MDR1 positive expression rate was 35.00%, between the two groups was significant difference (P lt; 0.01). MDR1 in the invasion and serosal layer and not invading the serosa of patients with gastric carcinoma were 88.46%, 53.57%, the test demonstrated a significant difference (P lt; 0.01); in lymph node metastasis-positive and-negative Patients of MDR1 expression rates were 88.10%, 63.16%, the test proved to have a significant difference (P lt; 0.01); in stage Ⅰ ~ Ⅱ and Ⅲ group of patients with MDR1 expression rates were 62.07%, 84.31%, after tests confirmed a significant difference (P lt; 0.05). Gastric negative and positive expression of MDR1 5-year survival rates were 78.95%, 32.79%, Log-rank test were significantly different timing (P lt; 0.01). (2) p53 in gastric cancer positive expression rate was 63.75%, in 20 cases in the control group, the positive expression rate of 5.00% between the two groups was significant difference (P lt; 0.01). p53 in invading the serosa and without invading the serosa of patients with gastric carcinoma were 82.70%, 28.57%, confirmed by chi-square test was significant difference (P lt; 0.01); in lymph node-positive and-negative patients with p53 expression rates were 90.48%, 60.53%, by chi-square test confirmed a significant difference (P lt; 0.01); in stage Ⅰ ~ Ⅱ and Ⅲ group of patients with p53 expression rate was 41.38%, 76.47%, by chi-square test confirmed a significant difference (P lt; 0.01); gastric negative and positive expression of p53 5-year survival rates were 72.41%, 27.45%, Log-rank test were significantly different timing ( P lt; 0.01). (3) VEGF in gastric carcinoma, the positive expression rate was 65.00%, in 20 cases in the control group, the positive expression rate was 10.00%, between the two groups was significant difference (P lt; 0.01). VEGF in invading the serosa and not invading the serosa of patients with gastric carcinoma were 84.62%, 28.57%, confirmed by chi-square test was significant difference (P lt; 0.01); in lymph node-positive and negative patients VEGF expression rates were 85.71%, 42.11%, by chi-square test confirmed a significant difference (P lt; 0.01); in Ⅰ ~ Ⅱ, Ⅲ stage group of patients with VEGF expression rate was 41.38%, 78.43%, by chi-square test confirmed a significant difference (P lt; 0.01); gastric negative and positive expression of VEGF in the 5-year survival rates were 67.86%, 30.77%, Log-rank test were significantly different timing ( P lt; 0.01). (4) The Spearman rank correlation analysis confirmed, MDR1 and p53 in gastric carcinoma were positively correlated (r = 0.251, P = 0.025); and VEGF expression was positively correlated (r = 0.329, P = 0.003); p53 and VEGF gastric cancer was positively correlated (r = 0.373, P = 0.001). (5) no time serosa with gastric cancer invading the serosa 5-year survival rates were 71.43 percent and 28.85 percent, the Log-rank test was significant timing differences (P lt; 0.01). Node-negative group and positive group of 5-year survival rates were 63.16 percent and 26.19 percent, the Log-rank test was significant timing differences (P lt; 0.01). Ⅰ ~ Ⅱ and Ⅲ in patients with 5-year survival rates were 72.41% and 27.45%, the Log-rank test was significant timing differences (P lt; 0.01). (6) Cox multivariate regression analysis showed: the depth of invasion, TNM stage and p53 expression levels of reliability are the most important independent prognostic factors (P lt; 0.01). Conclusions (1) MDR1, p53 and VEGF in gastric cancer tissues was significantly higher than in adjacent tissue, and with the depth of invasion, clinical stage, lymph node metastasis, indicating the occurrence and development of gastric cancer, combined detection of three The expression is important to determine the biological characteristics of gastric cancer molecular biology signs. (2) gastric cancer MDR1, p53 and VEGF expression was significantly correlated, indicating that three in the invasion and metastasis of gastric cancer there are some links. (3) MDR1, p53 and VEGF expression and prognosis of patients with gastric cancer, gastric cancer tissue expression of the three help determine the patient's prognosis. (4) a variety of factors affect the prognosis of gastric cancer, the depth of invasion, TNM stage and p53 expression levels of reliability are the most important independent prognostic factor.
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