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Study on the Association between CETP Gene Polymorphism and Cerebral Infarction of Han Population in Hunan Province

Author: LiHuaXiang
Tutor: XuHongWei
School: Central South University
Course: Neurology
Keywords: cholesterol ester transfer protein atherosclerosis cerebral infarction genetic polymorphism
CLC: R743.33
Type: Master's thesis
Year: 2011
Downloads: 21
Quote: 0
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Abstract


Objective To explore the association of cholesterol ester transfer protein gene Taq IB and -629C/A polymorphism with atherosclerosis cerebral infarction (CI) in Han population in Hunan province, and the possible influence of this SNP on blood pressure, serum lipid and fasting glucose.Methods Polymerase chain reaction-restriction fragment length polymorph (PCR-RFLP) was performed to identify the distributions of allele and genotype frequencies of SNP Taq IB and -629C/A polymorphism in cholesterol ester transfer protein gene in 238 patients with atherosclerosis CI and 162 healthy controls. Meanwhile we tested the levels of blood pressure, serum lipid, fasting glucose and BMI. All data was analyzed by SPSS 13.0.Results1. There is no significant difference of CETP Taq IB gene B1B1, B1B2, B2B2 genotype and B1 or B2 allelic distribution between CI patients and controls (P>0.05).2. There is no significant difference of CETP -629C/A gene AC, AC, CC genotype and A or C allelic distribution between CI patients and controls (P>0.05).3.The difference of blood lipids, blood sugar(FBS),blood pressure, history of hypertension, coronary heart disease, diabetes between CETP Taq IB B1B1 and B1B2+B2B2 gene type are not significant(P>0.05).4.The difference of blood lipids, blood sugar(FBS),blood pressure, history of hypertension or diabetes between CETP -629C/A CC and CA+AA gene type are not significant(P>0.05). History of coronary heart disease in CC genotype compared CA+AA genotypes were significantly (P<0.05).5. There are no significant differences between 4 combined gene types in lipids, glucose, blood pressure and history of hypertension, coronary heart disease, diabetes mellitus (P> 0.05).Conclusions1. The Taq IB and -629C/A polymorphism of CETP gene may not correlate with atherosclerosis cerebral infarction in Chinese Han population in Hunan province.2. There is no relationship between Taq IB polymorphism of CETP gene and blood lipids, FBS or blood pressure in Chinese Han population in Hunan province. The same to -629C/A polymorphism of CETP gene.3. There is no relationship between the polymorphism of Taq IB and -629C/A combined genotype and blood lipids, FBS or blood pressure in Chinese Han population in Hunan province.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke) > Cerebral embolism
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