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Xinjiang Uygurs and Hans Phosphodiesterase 4D Gene SNP83 Polymorphism Analysis of Ischemic Cerebrovascular Disease

Author: PeiJing
Tutor: ZhangXiaoNing
School: Xinjiang Medical University
Course: Neurology
Keywords: Uygurs and Hans Ischemic cerebral vascular disease Phosphodiesterase 4D gene Polymorphism
CLC: R743.3
Type: Master's thesis
Year: 2011
Downloads: 23
Quote: 0
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Abstract


Objective:To investigate the relationship of the PDE4D gene SNP83 polymor-phisms and ICVD between Uygurs and Hans population in Xinjiang. Methods:207 ICVD patients (98Hans,109Uygurs) and 216 healthy controls (99 Hans,110 Uygurs) are collected in xinjiang.The polymorphism of the PDE4D gene were determined by the PCR-restriction fragment length polymorphism technique. The case-control analysis was adopted to analyze the frequencies of genotypes and alleles. Results:1) The genotypes of PDE4D gene were consistent with Hardy-Weinberg equilibrium in both ICVD group (Uygurs:χ2=0.028, P>0.05 Han:χ2=1.945, P>0.05) and control group (Uygurs:χ2=4.555, P>0.05 Han:，χ2=8.69, P>0.05).2) There is statistical difference in the distribution of genotypes and allele frequency of PDE4D gene between ICVD group and control group (P<0.05).3) Divided by nation, the frequencies of CC genotype and C allele in Han patients is higher than that in Han controls (P<0.05), which has statistical difference; while there is no statistical difference in the distribution of the genotypes and allele frequency between Uygur’s ICVD group and control group.4) Divided by sex, the frequencies of genotypes and alleles of the PDE4D gene in male patients are higher than that in male controls (P<0.05), and the male individual carrying the C allele has a notably increasing occurrence of ICVD (OR=6.486, P<0.05); while there is no statistical difference in the distribution of genotypes and allele frequency between female-ICVD group and female-control group.5) Divided by the history hypertension, the distribution of genotypes and allele frequency of the PDE4D gene has statistical difference between the ICVD group who have the history of hypertension and the control group who have the history of hypertension (P<0.05), and the individual carrying C allele among them has a notably increasing occurrence of ICVD (OR=5.202,P<0.05); while there is no statistical difference in the distribution of genotypes and allele frequency between ICVD group who have no the history of hypertension and control group who have no the history of hypertension. Conclusion:PDE4D gene SNP83 polymorphisms have statistical differences between Chinese XinJiang Uygurs and Hans population.There might be an association between PDE4D gene SNP83 polymorphisms and the morbidity risk of ICVD among the population, who are Hans, or who are male, who have the history of hypertension.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
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