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The Experimental Study on the Artificial Nerve Tissue Graft Repaired Rat Sciatic Nerve Defect of 3 and 6 Months

Author: JiaoHaiShan
Tutor: WangXiaoDong
School: Nantong University
Course: Human Anatomy and Embryology
Keywords: Artificial tissue nerve graft Old peripheral nerve defects Nerve regeneration
CLC: R651.3
Type: Master's thesis
Year: 2008
Downloads: 68
Quote: 0
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Abstract


Objective To study the artificial tissue nerve graft (hereinafter referred to as \Adult female SD rats methods resection left sciatic nerve 4mm 3 months, 6 months, respectively, keeping trim made of rat sciatic nerve defect model of 10mm long. Experimental group to the of Artificial Neural bridging defects, the autogenous nerve repair as a positive control and the defect continued exclusion as a negative control. And set artificial nerve sciatic nerve the acute defect its defect repair old reference, the animals bridging postoperative feeding 3 months (3 months defect model part of the experimental animals fed for six months after repair) drawn through electrophysiological detection, FG retrograde tracing, histological examinations (muscle, nerve) indicators learn the artificial nerve defect of rat sciatic nerve for a long time. Result, the bridge is repaired, most of the experimental animals have been able to successfully recorded CMAPs, but the defect incubation period is longer than the experimental group in June defect Mar. experimental group (p lt; 0.05), amplitude and conduction velocity less. Two experimental groups have encountered in bridging physical middle and distal anastomosis beyond that observed in the regeneration of nerve fibers, nerve fiber density of defects in March the experimental group is greater than the June group FG retrograde labeled to the number of neurons and fluorescence strength with the defect time prolonged downward trend. Gastrocnemius wet weight and wet weight is less than the difference between the two experimental groups, the muscle fiber size defect March experimental group slightly larger (p LT; 0.05), the degree of collagen fibers defect June experimental group more significantly (p LT; 0.05) , muscle endplate degeneration similar muscle fiber atrophy. The two positive control group in nerve regeneration is slightly better than the corresponding experimental group, but the muscle recovery obvious advantages. Unrepaired group of nerve growth, severe muscle denervation atrophy; unrepaired group was not significantly different. The acute reference group observed most of these indicators should be better than the two old defect experimental group to extend the time of repair after nerve growth observed nerve growth and target organ recovery on all with corresponding defect repair experimental group in March in March difference, but unobvious advantages. Conclusion 1. Within a certain period, the old peripheral nerve injury still has a fix value. Artificial neural able to repair a certain extent the old peripheral nerve defects, but its repair the acute defect compared there is still a certain gap. Extend the repair of nerve regeneration time, it is possible to improve the effect of the artificial neural repair old nerve defects.

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CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Peripheral nerve
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