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Comparative Study on the Distributive Characteristics of Impaired Glucose Metabolism Subcategories and Its Influencing Factors between Korean and Han Nationality

Author: SunNan
Tutor: FangJinNv
School: Yanbian University
Course: Health Toxicology
Keywords: Impaired fasting glucose Diabetes Abnormal glucose metabolism Influencing factors Korean Han
CLC: R587.1
Type: Master's thesis
Year: 2008
Downloads: 28
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Abstract


Objective: comparative analysis of the distribution of the characteristics of the Korean and Han of Yanbian region crowd abnormal glucose metabolism and its influencing factors. Methods: ① Antu county, Yanbian Korean Autonomous Prefecture in August 2005 to August 2006, using a simple random sample of methods to extract more than 30-year-old Korean and Han ordinarily resident in 3156 to investigate. Select the object of the study excluded people suffering from serious organic disease, and be included in the study investigating the contents of informed consent. ② information collected in this survey in selected communities and their hospitals, home visits and healthy form. ③ before the survey. Rigorous training for all investigators to standardize the survey content, operational processes and methods, in accordance with a uniform questionnaire to conduct home visits interview survey. (4) measuring height (Height, Ht), weight (Weight, Wt), the waist (Waistcircumference WC), Hip (Hip circumference, HC), blood pressure, etc.. ⑤ take fasting (fasting 12h) venous blood, using automatic biochemical analyzer, serum total cholesterol (Total cholesterol, TC), triglycerides (Triglyceride, TG), high-density lipoprotein cholesterol (high-density lipoprotein cholesterol , HDL-C), blood glucose (Fasting blood glucose, FBG) and other indicators. ANOVA test ⑥ measurement data line x 2 and u-test was used to compare the count data. The different abnormal glucose metabolism influencing factors were analyzed using multivariate regression analysis, different glucose metabolism abnormalities as the dependent variable, gender, ethnicity, age, overall obesity, various types of abdominal obesity, hypercholesterolemia, high triglycerides hypertriglyceridemia, mixed hyperlipidemia, hypertension and its subtypes as independent variables, logistic regression analysis, the the BACKWARD method to select variables, and α = 0.05 for the selected variables significant resistance level α = 0.10 to remove variables significantly standards. Results: the total number of cases into the analysis of the results for 3156, which Korean 1357 (566 male, 791 female), accounting for 43.0%; 1799 Han (653 men, 1146 women) accounted for 57.0%. ① Korean and Han men fasting blood glucose (FBG) mean respectively 5.48,5.31 mmol / L, women were 5.31,5.36 mmol / L, no statistically significant difference. ② mildly impaired fasting glucose (IFG 1 , FBG ≥ 5.6 ~ 6.0mmol / L) crude rate of Korean and Han men were 10.8% and 13.5%, respectively, the age-adjusted standardized prevalence rate of 12.4% and 13.2%, respectively, which standardized prevalence of Han men Korean men, the difference was statistically significant (P <0.01). Korean and Han women IFG 1 crude prevalence rates were 10.0% and 11.0%, the prevalence rates were 9.0% and 11.4%, respectively, in which the female Han standardized high prevalence in North Korea ethnic women, the difference was statistically significant (P <0.01). Korean and Han men moderate fasting glucose impaired (IFG to 2 , FBG ≥ 6.1 to 6.9 mmol / L), the crude prevalence of 9.4% and 8.6%, respectively, the age-adjusted standardized prevalence 8.7% and 7.9%, respectively, which Korean male standardized prevalence Han males, the difference was statistically significant (P <0.01). Korean and Han women IFG 2 crude rate of 8.0% and 5.9%, its standardized prevalence were 6.8% and 5.9%, higher than the standardized prevalence of Korean women Han women, the difference was statistically significant (P <0.01). Korean and Han men with diabetes (DM, FBG ≥ 7.0 mmol / L) crude rate of 12.7% and 6.6%, respectively, the age-adjusted prevalence rates were 11.1% and 4.8%, regardless crude prevalence or marked The prevalence rates of Korean males were significantly higher than in Han (P <0.01). Korean and Han women DM crude prevalence were 9.4% and 7.0%, respectively, the standardized prevalence rate of 6.5% and 6.5%, respectively, regardless crude prevalence or standardized prevalence of the differences were not statistically significant. North Korea, Han men and women IFG 1 and IFG 2 prevalence rate increased with age and elevated the increasing trend was statistically significant (P <0.05). Toward Han men and Korean women DM prevalence with age but increased with increasing trend was statistically significant (P <0.05), the female Han DM Age was no significant difference. ③ Korean hyperglycemic IFG the IDG 2 and DM proportion were 34.8%, 28.9%, 36.3%, 32.8% male group 28.5%, 38.7%, women 36.6%, 29.2%, 34.3%; Han hyperglycemic to IFG 1 the IDG 2 and DM proportion respectively 46.4%, 26.9%, 26.7%, male group was 47.1%, 29.9%, 23.0%, women 46.0%, 24.8%, 29.2%. Korean population the DM more common, while Han IFG 1 more common. The different abnormal glucose metabolism nation Distribution slightly different, and the differences in the proportion of patients with different ages. ④ Korean and Han populations, with fasting glucose levels increased severity of abnormal glucose metabolism, the average age and BMI, WC, WHR, WHtR, SBP, TG, TC, HDL-C and other parameters increased gradually ( P <0.05). Korean and Han populations, with fasting glucose levels increased, overall obesity, the various abdominal obesity, isolated systolic hypertension (Han), systolic hypertension merger diastolic hypertension, high blood pressure, hypertriglyceridemia mixed hyperlipidemia and dyslipidemia prevalence showed a trend of gradually increased (P <0.05). ⑤ multivariate analysis results show that: a) to enter the main effects model of factors that affect the the mildly impaired fasting blood glucose (FBG ≥ 5.6 ~ 6.0mmol / L) were independent factors of age (increase), gender (male), WHtR WHR, high-density lipoprotein cholesterol (lower), hypertriglyceridemia, mixed hyperlipidemia, isolated systolic hypertension; b) to enter the main effects model of factors that influence the moderately impaired fasting blood glucose (FBG ≥ 6.1 ~ 6.9 mmol / L) occurred independent nation (Korean), gender (male), age (increasing), WHtR, WHR, high-density lipoprotein cholesterol (lower), hypertriglyceridemia, mixed hyperlipidemia; c) into the model of the main effects of factors that affect diabetes (FBG ≥ 7.0 mmol / L) occurred independent nation (Korean), gender (male), age (increase), WHtR WHR, hypertriglyceridemia, mixed hyperlipidemia. Conclusions: 1) the general population abnormal glucose metabolism higher prevalence level, the level of its prevalence increases with age. The different ethnic groups in different prevalence of abnormal glucose metabolism, there are obvious differences. 2) in different abnormal glucose metabolism population, the Korean population with DM are more common, more common Han the Zeyi mild fasting glucose and impaired. Population of abnormal glucose metabolism, glucose metabolism abnormalities constitute the ethnic distribution in slightly different ratio, and the differences in the proportion of patients with different ages. 3) with fasting blood sugar levels or severity of abnormal glucose metabolism, average age and BMI, WC, WHR, WHtR, SBP, TG, TC, HDL-C and other parameters were gradually increasing trend (P <0.05), the overall obesity, the various abdominal obesity, isolated systolic hypertension (Han), systolic hypertension combined diastolic hypertension, hypertension, hypertriglyceridemia, mixed hyperlipidemia and dyslipidemia prevalence with fasting glucose levels increased gradually (P <0.05). 4) the different abnormal glucose metabolism the nation (Korean), gender (male), age (increases), abdominal obesity, high-density lipoprotein cholesterol (lower), hypertriglyceridemia, mixed hyperlipidemia hyperlipidemia, isolated systolic hypertension were significantly associated, and the different distribution characteristics in different abnormal glucose metabolism.

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
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