Dissertation > Excellent graduate degree dissertation topics show

The Relation of NAD(P)H Oxidase P22phox C242T Polymorphism with Type 2 Diabetes Mellitus Carotid IMT

Author: LiLan
Tutor: PuLianShan
School: Yanbian University
Course: Internal Medicine
Keywords: Type 2 diabetes mellitus P22phoxC242T Carotid IMT Arteriosclerosis
CLC: R587.2
Type: Master's thesis
Year: 2008
Downloads: 15
Quote: 0
Read: Download Dissertation

Abstract


Objective: To investigate the NAD (P) H oxidase P22phox subunit C242T gene polymorphism in the Yanbian area distribution of the Han Chinese and Korean groups and type 2 diabetes with carotid atherosclerosis research. Research Subjects and Methods: Study subjects: randomly selected Yanbian region of Han and Korean groups, including normal control group (normalglucose tolerant, NGT) the Han 120 cases, Korean 102 cases, type 2 diabetes mellitus (type 2 diabetesmellitus, T2DM) Han 273 Example, Korean 186 cases. Diabetic patients with carotid intima - media thickness (intima-media thickness IMT) is divided into four groups: ① type 2 diabetes mellitus positive group with carotid atherosclerosis (IMT ≥ 1.0 and / or plaque formation); ② The type 2 diabetes mellitus neck the atherosclerosis-negative group (IMT <1.0 and no plaque); ③ Korean 2 diabetes carotid atherosclerosis positive group (IMT ≥ 1.0 and / or plaque formation); ④ Korean type 2 diabetic carotid atherosclerosis negative group (IMT <1.0 and no plaque). Research methods: using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method to determine the genotype, the use of B-type color Doppler detection of carotid IMT clinical indicators detected. Groups between the genotype and allele frequencies and groups of measurement data by one way ANOVA variance analysis for the statistical analysis by Logistic regression analysis, screening of carotid atherosclerosis disease risk factors, the resulting data using SPSS13.0 software for statistical Analysis. Results: (1) Han of Yanbian region control group of NAD (P) H oxidase P22phox subunit C242T gene polymorphism distribution characteristics for CC (77.5%), CT (20.4%), TT (2.5%), its allelic gene frequency C / T (87.5% / 12.5%); Korean control group of NAD (P) H oxidase P22phox subunit C242T gene polymorphism distribution characteristics for CC (87.3%), CT (10.7%), TT ( 2.0%), the allele frequency of the C / T (92.6% / 7.4%), P> 0.05. (2) in patients with type 2 diabetes in the Yanbian region the Han groups NAD (P) H oxidase P22phox subunit C242T gene polymorphism distribution characteristics for CC (72.5%), CT (25.6%), TT (1.8%), its equivalent allele frequency for the C / T (85.3% / 14.7%); the Korean group NAD (P) H oxidase P22phox subunit C242T gene polymorphism distribution characteristics of CC (84.9%), CT (12.4%), TT ( 2.7%), the allele frequency for the C / T (91.1% / 8.9%), P <0.01. (3) each of the Yanbian area the Han control group and type 2 diabetes mellitus, Korean control group and type 2 diabetic group compared contrast distribution, P> 0.05. (4) in patients with type 2 diabetes in the Yanbian region Han arteriosclerosis positive group and negative group CC the the CT TT distribution frequency 81.8% VS67.2%, 18.2% VS32.8%, P <0.01. (5) patients with type 2 diabetes in the Yanbian area Korean arteriosclerosis positive group and negative group CC the the CT TT distribution frequency 89.2% VS82.1%, 10.8% VS17.9% (P> 0.05). (1) Logistic regression analysis showed that age and Yanbian Han patients with type 2 diabetes group B value 0.914, OR value of 2.493, P = 0.000; age and Yanbian Korean type 2 diabetes patients in group B value 1.005, OR, the value of 2.732 , P = 0.000. Conclusion: (1) patients with type 2 diabetes in Han and Korean Yanbian area of ??NAD (P) H oxidase subunit C242T groups P22phox distribution differences. (2) T allele Yanbian Han type 2 diabetes group arteriosclerosis protective gene, and Yanbian Korean patients with type 2 diabetes unrelated. (3) Age is an independent risk factor for atherosclerosis Han and Korean in Yanbian.

Related Dissertations

  1. Relationship between Level of Serum Uric Acid and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  2. Efficacy and Safety of Biphasic Insulin Aspart 30 Once-daily Treatment in Patients with Type 2 Diabetes,R587.1
  3. The Blood Glucose Control and Influencing Factors in Type 2 Diabetic Patients with Oral Hypoglycemic Agents,R587.1
  4. The Evaluation of Arterial Early Damage in High-normal Blood Pressure Population,R544.1
  5. Association of Genetic Variation of UTS2 Gene with Type2 Diabetes Mellitus and Hypertension,R587.1
  6. Effect of Gastric Bypass on the Blood Glucose Level in Type 2 Diabetes Rat Model,R587.1
  7. Relationship between Postprandial Blood Pressure and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  8. The Characteristics of Coronary Angiography in Type 2 Diabetes Mellitus Patients with Suspected Coronary Artery Disease,R587.1
  9. Effect of Whey Protein on Improving Insulin Resistance and the Underlying Mechanisms,R587.1
  10. Correlation Studies of Plasma Fatty Acids and Type 2 Diabetes Mellitus: Case Control Study,R587.1
  11. Effects of New Intravenous Infusions on Blood Glucose Variability in Elderly Type 2 Diabetic Patients,R587.1
  12. Comparison of Differences in Bone Mineral Density and Its Related Factors for Patients with Type 2 Diabetes Mellitus of Han, Uygur Nationalities in Xinjiang,R587.1
  13. Energy Supply and Nutritional Intervention Study in Hospitalized Patients with Type 2 Diabetes,R587.1
  14. Expression of Chemerin in Liver of Diet Induced Type 2 Diabetic Rats with IL-6 Intervention,R587.1
  15. Huanglianjiedu Tonga flavor particles combined basal insulin , metformin onset obesity, type 2 diabetes clinical observation,R587.1
  16. Study on the Association of the Brain-derived Neurotrophic Factor and Type 2 Diabetes Mellitus with Depression,R749.2
  17. GAD-Ab, ICA, IAA in LADA Expression and Clinical Significance,R587.1
  18. The Association between Pigment Epithelium-Derived Factor and Urinary Albumin Excretion Rate in Type 2 Diabetes Mellitus,R587.1
  19. Insulin Sensitizers and Insulin Secretion Promoting Agents Suitable for Which Type 2 Diabetic Patients?,R587.1
  20. The Correlated Research about IL-1β、PGE2 with Insulin Section and Function in Type 2 Diabetes Mellitus,R587.1
  21. The Therapy of Microalbuminuric Patients with Type 2 Diabetes Mellitus and Hypertension,R587.1

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetic coma and other complications
© 2012 www.DissertationTopic.Net  Mobile