Dissertation > Excellent graduate degree dissertation topics show

The Study of Myositis Autoantibody and Muscle Magnetic Resonance Imaging in Polymyositis and Dermatomyositis

Author: HouZuoHong
Tutor: ZhangLiZuo
School: Shanxi Medical
Course: Internal Medicine
Keywords: polymyositis dermatomyositis myositis-specific autoantibodies magnetic resonance imaging
CLC: R593.26
Type: Master's thesis
Year: 2009
Downloads: 105
Quote: 1
Read: Download Dissertation

Abstract


Background1. The polymyositis and dermatomyositis (PM / DM) is a kind of connective tissue disease (CTD), which is easy to violations of multi-organ, multi-system. It is difficult to achieve early diagnosis and treatment because of the complexity of clinical manifestations.In recent years it is be found that there is a series of auto-antibodies in the serum of PM/DM patients. They are myositis-specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs). MSAs can be divided into three categories: anti-synthetase(ARS) antibodies, anti-SRP antibody and anti-Mi-2 antibody. The anti-synthetase(ARS) antibodies include anti-Jo-1 antibody, anti-PL-7 antibody and anti-PL-12 antibodies, such as. MAAs include anti-Ku-72 antibody, anti-Ku-86 antibody and anti-PM-Scl antibody and so on. The Study abroad reported that MSAs and the clinical symptoms and prognosis are closely related. Less coverage of domestic parties, there are good prospects for clinical application.2. The magnetic resonance imaging(MRI) contribute to PM / DM diagnosis. Magnetic resonance imaging (MRI) has the high sensitivity of soft tissue, and can inspecte repeatly and observate dynamicly.At present, MRI has been used abroad diagnosis to muscle disease. We has not been enough attention.ObjectiveThrough the detection of myositis autoantibody spectru of PM/DM patients to explore its PM / DM diagnosis value; Through the examination of MRI, we discuss the diagnosis value for PM/DM of MRI.Methods1.Myositis myositis autoantibody testing:①The study object: There were 260 serum specimens which come from 56 PM/DM, 163 connective tissue diseases(CTD), 41 spondyloarthropathies(SpA)patients and 30 healthies.②Detected their myositis-specific autoantibodies (MSAs) and myositis-associated auto-antibodies (MAAs) by Myositis antibody repertoire. Detected their 7 kinds of antibody in which anti Jo-1, anti PL-7, anti-PL-12, anti-Mi-2 antibody were MSAs and anti- Ku-72, anti- Ku-86, anti-PM-Scl antibody were MAAs by Myositis antibody repertoire with Western blotting.2. The muscle MRI examination: ①The study object: PM / DM patients with a total of 35 cases, of which PM11 cases, DM24 cases; healthy control group: 10 cases.②instruments and methods: The use of GE Vectra 1.5T superconductive MRI scanners,the ptional body coil coronal scan. Conventional spin echo (SE), including T1-weighted image (T1WI) and T2-weighted image (T2WI) and short time inversion recovery (STIR) check. Scan parts: buttocks and lower limbs.Results1. The spectrum myositis autoantibody test results:①The 7 myositis autoantibodies sensitive species are as follows: anti-Jo-1 antibody (23.2%), anti-PL-7 antibody (8.9%), anti-PL-12 antibodies (10.7%), anti-Mi-2 antibody (8.9%), anti-Ku-72 antibody (10.7%) , anti-Ku-86 antibody (14.3%), anti-PM-Scl antibody (5.4%);Specificity respectively: Anti-Jo-1 antibody (99.0%), anti-PL-7 antibody (98.5%), anti-PL-12 antibodies (99.5%), anti-Mi-2 antibody (99.0%), anti-Ku-72 antibody (78.9%), anti-Ku-86 antibody (82.8%), anti-PM-Scl antibodies (92.2%).②The sensitivity of anti-synthetase antibody jointted detection of the PM/DM was significantly higher than a separate detection of anti-Jo-1 antibody (P <0.05), no significant decline in specificity.③anti-synthetase antibodies associated with clinical symptoms:the major clinical manifestations of anti-synthetase-positive patients are myalgia, myasthenia gravis, arthritis, interstitial lung disease, fever and Raynaud’s phenomenon. The positive rate is higher than the negative control group.2. The muscle MRI Results:①control group: the signal for the muscle tissue between cortical bone and subcutaneous fat between the moderate- intensity and more even signal.②PM/DM group: the 7 cases of PM and DM for the 12 cases of pure muscle edema, 4 cases of PM and DM for the seven cases is fatty infiltration of muscle edema combined (duration> 1 year). Muscle edema was slightly lower in T1WI sequence to signal, T2WI and STIR sequence showed multiple patchy distribution of small high-signal; fatty infiltration in both T1WI and T2WI showed high signal, and STIR sequences, such as low signal . Conclusions1. The MSAs for PM/DM has high specificity. A number of MSAs increased the joint detection so sensitive and help to raise the PM / DM patients with the diagnosis.2. The muscle MRI examination can be used in muscle lesions of suspicious PM/DM patients. It will help improve the diagnosis rate of the DM/PM patients.

Related Dissertations

  1. MRI Guoded Experimental Cryoablation of Rabbit’s Sciatic Nerve for MRI and Pathology Contrast Study,R445.2
  2. The Clinic Value of Diffusion Weighted Whole Body Imaging with Background Body Signal Suppression (DWIBS) Compared with hPET/CT,R445.2
  3. A Volumetric Study of External Capsule, Extreme Capsule and Inferior Frontal Gyrus White Matter in First-Episode Paranoid Schizophrenia,R749.3
  4. Healthy Chinese central olfactory structures related to MRI volume and olfactory function with age correlation,R445.2
  5. Progressive supranuclear palsy clinical and magnetic resonance imaging characteristics of,R741
  6. The Resting-state fMRI Study of Secondary Generalized Epilepsy,R742.1
  7. The Expression and Significance of Lysosomal Cathepsin B on the Coxsackievirus B1-Induced Polymyositis Model in the Guinea Pigs,R746.5
  8. Clinical Effects, Imaging Study and Treatment of TOT Procedure Combined with Modified Pelvic Floor Reconstruction on Female Stress Urinary Incontinence,R699.7
  9. MRI sagittal lumbar disc T_2 map classification in the application and quantitative analysis,R681.5
  10. Optimal Design of Main Magnet in Magnetic Resonance Imaging (MRI),O482.532
  11. A Characteristic Comparison of MRA and Its Clinic Study on the Diabetes and Non-diabetes Acute Cerebral Infarction,R743.3
  12. Depression in patients with resting state functional magnetic resonance,R749.4
  13. Serum Levels of IL-18 in Patients with Polymyositis and Dermatomyositis,R593.26
  14. Imaging Research of Chronic Cerebral Ischemia,R743.3
  15. Radiologic and Clinical Feature of Corpus Callosal Infarction,R743.33
  16. Early False-negative Diffusion-weighted Imaging in Acute Ischemic Stroke,R743.3
  17. The Usefulness of Breast MRI in the Diagnosis and Differential Strategy for Lesions Showing Ductal and Segmental Enhancement,R737.9
  18. Evaluation of MRI and DCE-MRI in the Preoperative Staging of Rectal Cancer,R735.37
  19. Limbic-cortical Dysfunction in Patients with Major Depresion: an Event-related fMRI Study with the Negative Priming Task,R749.4
  20. 300 Cases of Lacunar Cerebral Infarction Clinical Data Were Analyzed Retrospectively,R743.33
  21. Spatial Working Memory Dysfunction in Minimal Hepatic Encephalopathy: Ethology and BOLD- fMRI Study,R747.9

CLC: > Medicine, health > Internal Medicine > Systemic disease > Autoimmune diseases > Autoimmune diseases, connective tissue disease > Dermatomyositis
© 2012 www.DissertationTopic.Net  Mobile