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Objective To investigate the impaired glucose regulation (IGR) with non -alcoholic fatty liver disease (NAFLD) in patients with serum adiponectin (APN), leptin (Leptin) and adiponectin / leptin ratio (A / L) and insulin resistance ( IR) correlation . Methods from our hospital and medical center by the OGT-F (75g oral glucose tolerance test ) screening healthy controls , 30 cases of impaired fasting glucose (IFG) , 32 patients with NAFLD , do not merge in 30 cases , IFG impaired glucose tolerance (IGT) , 32 patients with NAFLD , do not merge in 30 cases . IGR group including IFG and IFG IGT without NAFLD without NAFLD total of 60 cases , IGR FL NAFLD group includes IFG and IFG IGT combined total of 64 cases with NAFLD . Anthropometric parameters measured to calculate body mass index (BMI) and waist-hip ratio (WHR), fasting plasma glucose (FPG), lipids , liver function, serum fasting insulin (FINS), serum APN and Leptin levels , FPG was 5.6-6.9mmol / L were OK OGT-F load measured after 2 hours after glucose load , the homeostasis model assessment of insulin resistance index (HOMA-IR) and A / L ratio . Results ① IGR FL serum APN, A / L was significantly lower than that IGR group (P <0.05), HOMA-IR, Leptin was significantly higher (P <0.05). ② Serum FINS, FPG, Leptin, APN parameters associated with IR analysis , APN (r = -0.451, P <0.001) and Leptin (r = 0.748, P <0.001) is IR's major relevant factors , IGR FL group of related factor than simply IGR group . ③ A / L, HOMA-IR and IR analysis of the correlation parameters , A / L of the correlation coefficient is greater than HOMA-IR, IGR FL Correlation Coefficient than simply IGR group . ④ A / L, HOMA-IR and IR parameters of multiple linear regression analysis : In the 60 cases of simple IGR group , WHR, TG for A / L have a significant impact ; WHR right HOMA-IR were significantly affected ; between the coefficient of determination (R ~ 2 ) were 0.3011 and 0.1503 . In 64 cases IGR FL group , WHR, TG, LDL-C on the A / L have a significant impact ; WHR right HOMA-IR were significantly affected ; Both R ~ 2 were 0.3719 and 0.1217 . Conclusion ① IGR lower serum adiponectin , leptin increases , A / L ratio decreased and insulin resistance , with NAFLD is more pronounced. ② A / L ratio may be an effective indicator for the evaluation of IR rather than HOMA-IR. ③ BMI and WHR is affecting patients with NAFLD IGR adiponectin and leptin levels most important factor.
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