Dissertation > Excellent graduate degree dissertation topics show

Effects of Tirofiban on the sOX40L and Strain Rate in Patients with Coronary Heart Disease after Stent Treatment

Author: MaYanFeng
Tutor: GuoZhiBin
School: Nanchang University
Course: Internal Medicine
Keywords: sOX40L Tirofiban Coronary heart disease Percutaneous coronary intervention in patients Myocardial strain rate
CLC: R541.4
Type: Master's thesis
Year: 2009
Downloads: 44
Quote: 0
Read: Download Dissertation

Abstract

Objective: To observe tirofiban treatment of coronary heart disease patients after PCI plasma sOX40L content and myocardial strain rate (SR), the relationship between the severity of coronary to investigate plasma sOX40L content with coronary heart disease (CHD) and percutaneous coronary stent (stent) and significance behalf the tirofiban (tirofiban) after treatment sOX40L and SR change. : March 2007 to January 2009, 85 cases of hospitalized patients with suspected coronary artery disease undergoing coronary angiography (CAG), to evaluate the severity of coronary lesions in the number of diseased vessels and Gensini score, patients were divided according to angiographic results for coronary heart disease group (60 cases) and control group (25 cases), according to the clinical type, the number of coronary lesions, Gensini points to coronary heart disease patients were divided into three subgroups, depending on the treatment of coronary heart disease patients into two subgroups: the stent group and stent tirofiban. All patients before and after treatment with myocardial strain rate imaging (SRI) Determination of SR blood was measured plasma sOX40L content, high-sensitivity C-reactive protein (hs-CRP), fibrinogen (Fbg), white blood cell (WBC), blood lipids , blood glucose and other indicators, sOX40L hs-CRP, WBC, Fbg, hyperlipidemia, age indicators line Spearman correlation analysis. Results: (1) patients with coronary heart disease the plasma sOX40L content was significantly higher than that in the control group (P lt; 0.01) subgroups of unstable angina (UA) and myocardial infarction (MI) the subgroup sOX40L content was significantly higher than stable angina (SA ) subgroup (P lt; 0.01), MI the subgroup sOX40L content was significantly higher than the UA subgroup (P lt; 0.01). (2) sOX40 content with increasing the number of coronary lesions and Gensini score increases, there is a statistically significant difference (P lt; 0.01) among subgroups. (3) the plasma sOX40L content with hs-CRP was positively correlated (rp = 0.526, P lt; 0.01), low-density lipoprotein cholesterol (LDL-C) was positively correlated (rp = 0.589, P lt; 0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly negatively correlated (rp = -0.442, P lt; 0.05), and age, TG, TC, BMI, the WBC, Fbg no significant sex (P gt; 0.05 ). (4) stent group immediately after 24h the 36h sOX40L content compared with preoperative significantly increased, decreased postoperative of 10 days sOX40L content than before, but still higher than that in control group (P lt; 0.01). stent behalf of the Romanian non-team the immediate postoperative compared with preoperative sOX40L content was significantly higher, but the postoperative 24h and 36h sOX40L of content compared with the stent group decreased significantly compared with the stent group a significant difference (P lt; 0.01), postoperative 10 days sOX40L content of the control group had no significant difference (P gt; 0.05). (5) stent group and stent behalf of the Romanian non-team preoperative ischemic myocardial strain rate curve systolic, diastolic early and late diastolic SR peak is less than the normal segments (P lt; 0.05) can shrink shrink (PSS ) waves. stent group and stent tirofiban postoperative ischemic myocardial strain rate each peak gradually increased PSS wave disappeared, each index than untreated ischemic myocardium was significantly increased (P lt; 0.05), stent tirofiban surgery SR The degree of improvement was significantly higher than the stent group (P LT; 0.05). (6) the stent group and stent month behalf of the Romanian team hospitalization and after discharge did not occur major adverse cardiac events, thrombocytopenia and severe bleeding complications, stent tirofiban mild bleeding number of cases slightly more than the stent group. Conclusions: (1) patients with coronary heart disease the plasma sOX40L content was significantly higher than the control. (2) sOX40L concentration levels reflect the severity of coronary atherosclerosis lesions. (3) PCI surgery may result in increased plasma sOX40L content, may trigger inflammation reaction PCI, tirofiban therapy may reduce plasma sOX40L content tirofiban may have anti-inflammatory effects. (4) plasma sOX40L content with hs-CRP and LDL-C was significantly positively correlated with HDL-C was significantly negatively correlated, no significant correlation with age, TG, TC, BMI, WBC, Fbg etc.. (5) SRI can accurately identify ischemic segments in patients with coronary heart disease after PCI applications tirofiban treatment can more effectively improve ischemic myocardial blood supply, improve the ability of myocardial deformation. (6) the intracoronary application PCI intraoperative tirofiban safe, effective and feasible.

Related Dissertations

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
© 2012 www.DissertationTopic.Net Mobile