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Objective To successfully copied rabbit model of silicosis, to explore the impact of of Salvia medication early the silicosis in vivo oxidant / antioxidant imbalance in order to find an effective treatment for overcoming the early stage of silicosis and pulmonary fibrosis. Methods 60 healthy male rabbits, each weighing about 2.5 kg, were randomly divided into four groups, 1, normal control group, 2, Salvia drug treatment group, and low concentrations Miltiorrhiza lavage group, 4 pneumoconiosis control group of 15. 2-4 perfusion silica dust suspension group 1 the hungry poured into the same volume of physiological saline. After the model of silicon nodules found by biopsy to determine the success of silicosis rabbit model, rabbits exposed to silica 30d, 60d, 90d, respectively, using the thiobarbituric acid colorimetric method, xanthine oxidase rabbit serum MDA content and SOD activity change, nitrate reductase method for the determination of serum NO changes to determine the impact of Salvia on the the silicosis body oxidant / antioxidant imbalance. Results Of the 60 rabbits, the low concentration Miltiorrhiza lavage group had died two; pneumoconiosis death of one, a control group was not copied successfully. Rabbits exposed to silica 30d, 60d, 90d serum MDA content: 30d when pneumoconiosis control group rabbit serum MDA content and Salvia drug treatment group, the low concentration Miltiorrhiza lavage group was no significant difference (P gt; 0.05 ), more than three groups of MDA content compared with the normal control group was significantly higher (P lt; 0.05); 60d, when the 90 days, of pneumoconiosis the control group rabbit serum MDA content compared with normal control group, Salvia Salvia drug treatment group, low concentration liquid alveolar lavage group were significantly increased, and Salvia Salvia drug treatment group and the low concentration solution lavage group compared with the normal control group was significantly higher (P lt; 0.05), the difference was statistically significant. 2 rabbits exposed to silica 30d, 60d, 90d serum activity of SOD: when the 30 days, the control group of pneumoconiosis rabbit serum SOD activity and Salvia drug treatment group, low concentration Miltiorrhiza the lavage group was no significant difference (P gt; 0.05), more than three groups of SOD activity than those in the control group was significantly lower (P lt; 0.05); 60d, when the 90 days, the control group of pneumoconiosis rabbit serum SOD activity than normal control group, Salvia Salvia drug treatment group, low concentration liquid alveolar lavage group were significantly reduced, and Salvia Salvia drug treatment group and the low concentration solution lavage group compared with the normal control group was significantly lower (P lt; 0.05), the difference was statistically significant. (3) 30 days after the rabbits exposed to silica dust, 60d, 90d serum NO change: when 30d, pneumoconiosis control group rabbit serum NO Salvia Salvia drug treatment group, low concentration solution lavage was no significant difference (P gt; 0.05) more than three sets of NO content compared with the normal control group was significantly higher (P lt; 0.05); 60d, when the 90 days, the control group of pneumoconiosis rabbit serum NO compared with normal control group, Salvia drug treatment group, the low concentration Miltiorrhiza alveolar lavage group significantly increased, and Salvia Salvia drug treatment group and the low concentration of liquid lavage group compared with the normal control group was significantly higher (P lt; 0.05), the difference was statistically significant. Conclusion Salvia can effectively delay the process of silicosis in vivo oxidant / antioxidant imbalance, thereby delaying the development of early silicosis and pulmonary fibrosis.
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