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Atherosclerosis rat model of ADP and inflammatory factor expression and traditional Chinese medicine its control mechanism

Author: ChangBing
Tutor: LvXiaoDong
School: Liaoning University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: atherosclerosis adiponectin tumor necrosis factorα IL-6 CRP RT-PCR
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 19
Quote: 0
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Abstract


Purpose:To explore the relevance between expression level of adiponectin (ADPN) and tumor necrosis factorα(TNF-α).Material and method:216 wistar rats were randomly divided into six groups: control group, model group, Tōng Mài HuàZhuóTāng high dose group,Tōng Mài HuàZhuóTāng middle dose group, Tōng Mài HuàZhuóTāng low dose group, and Chinese medicinals control group. The atherosclerosis model was induced by feeding the rats with cholesterol-rich fodder. Then the medicinals were administered on these rats, 12 of which were executed in the fourth, sixth and eighth weeks counted from the day of administration. After the relevant tissues for research were taken, the expression levels of ADP and TNF-αin myocardial cell were tested using the technology of RT-PCR.Results:1. There is a positive relevance between expression level of ADPN and TNFα,2. and also there is an inhibitory effect of ADP on TNF-α. Above all,。3. recipes of Chinese medicine have clear regulatory effects on the expression of ADP.Conclusion:1. Tōng Mài HuàZhuóTāng is very promising both clinically.2. practically in its effect on controlling.3. treating atherosclerosis by promoting the level of ADP that inhibits the expression of TNF-α.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology
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