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Rhubarb Zhechong pill on S_ (180) tumor-bearing mice tumor cell apoptosis

Author: TianXiaoHuan
Tutor: AiHua
School: Liaoning University of Traditional Chinese Medicine
Course: Clinical basis for TCM
Keywords: Rhubarb Zhechong pill Tumor-bearing mice Inhibition Apoptosis
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 43
Quote: 0
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Abstract


Objective : Using mice as a research object , observe the rhubarb pill Zhechong inhibition of tumor cells and induction of apoptosis , aims to explore rhubarb Zhechong pill antitumor effector mechanisms , its clinical application and development of new medicines provide a theoretical basis . Methods: Mice Crowe 's (S 180 ) sarcoma animal model, tumor-bearing mice were divided into rhubarb Zhechong Pill high, medium and low dose group, with rhubarb Zhechong Pill 82g / kg, 41g/kg, 20g/kg dose intragastrically 10 days , while negative control ( model ) group and normal group and western medicine ( cyclophosphamide ) control group , the tumor inhibition rate ; cells was measured by flow cytometry apoptosis ; electron microscopy tumor cell ultrastructure ; Survivin expression was detected by in situ hybridization . Results: ( 1 ) rhubarb Zhechong pill high, medium and low dose group on mice tumor inhibition rates were 50.00% , 41.95% and 31.03% , compared with the model group were significantly different (P lt; 0.05, P lt ; 0.01 ) , especially in the high-dose pills rhubarb Zhechong significantly . ( 2 ) was observed under an optical microscope rhubarb Zhechong pill mice nests of tumor size and tumor cells significantly reduced the number of tumor cells was significantly reduced ; transmission electron microscope rhubarb Zhechong pill group murine tumor cell volume was significantly smaller , the cell surface microvilli decrease or even disappear, and apoptotic bodies . ( 3 ) Flow cytometry proved by rhubarb Zhechong pill treatment groups were seen in tumor cell apoptosis . ( 4 ) rhubarb Zhechong pill can reduce the treatment groups Survivin expression in tumor cells . Conclusion : Rhubarb Zhechong pill can inhibit S 180 mice tumor growth and tumor-bearing mice can promote tumor cell apoptosis , suggesting dahuangzhechongwan may be an effective anti-tumor therapy.

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