Dissertation > Excellent graduate degree dissertation topics show

Clinical Study of the Treatment of PF with Matrine Injection

Author: LiQiFang
Tutor: ChenXianHai
School: Shandong University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: matrine pulmonary fibrosis clinical trial
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 20
Quote: 0
Read: Download Dissertation

Abstract


Objective:To observe the effect of matrine injection on the lung mesenchymal fibrosis patient’s quality of life clinical smptoms and inflammatory factor.Methods:60 patients with lung mesenchymal fibrosisi were divided into two groups at random:the treatment group and the control group. The treatment group was given matrine injection,small amount of glucocorticoid and symptomatic treatment.The control group was small amount of glococorticoid and symptomatic treatment, 4 weeks were set as a course of treatment. The clinical effects of each group were observed during the course. Results:Clinical studies have shown that the treatment group,the quality of life in patients with pulmonary fibrosis, clinical symptoms and inflammatory factors were better than the control group. Treatment can significantly improve the quality of life of patients,improve breathing, coughing and other symptoms,serum levels of interleukin -4 (IL-4) levels were significantly decreased, the effective than the control group (P <0.05 or P <0.01).The two groups no adverse reactions during treatment.Conclusions:Matrine effective in the treatment of pulmonary fibrosis. The mechanism may be through inhibiting the expression of IL-4, thereby inhibiting the development of TH2 toTH0 reduce fibroblast proliferation and differentiation.

Related Dissertations

  1. Osthol on bleomycin- induced pulmonary fibrosis in rats and its mechanism of,R563.9
  2. The Dynamic Changes of Serum Cytokines in Paraquat Poisoning Rats and the Artesunate Intervention Studies,R595.4
  3. Effect of Xuebijing on Lung Fibrosis in a Rat Model of Oleic Acid-induced Lung Injury,R563.8
  4. Department of Respiratory Medicine, Union Hospital of Tongji Medicine College, Huazhong University of Science and Technology,R563.9
  5. The Effects of Rosiglitazone and Prednisone on the Expression of FIZZ1 in the Pulmonary Fibrosis Induced by Blemycin,R965
  6. A Randomized Controlled Trail of Early Clinical Outcomes of Fixed-versus Mobile-bearing Total Knee Arthroplasty,R687.4
  7. Observation of Percutaneous Kyphoplasty for Osteoporosis Vertebral Compression Fracture with High Viscosity Bone Cement,R687.3
  8. Matrine injection on the treatment of acute radiation enteritis and its mechanism,R285
  9. Nrf2, γ-GCS expression matrine bleomycin- induced pulmonary fibrosis,R285.5
  10. Clinical Research on the Effect of Matrine Soup on the Healing of Surgical Wounds of Anal Fistula,R285
  11. Study on Cow Nipple Protective Membrane of the Research and Clinical Trial,S858.23
  12. Effect of N-acetyl-seryl-aspartyl-lysyl-proline on the Proliferation and Collagen Synthesis in Cultured Rat Pulmonary Fibroblasts Through JNK Signal Transduction Mediated by TGF-β1,R563
  13. The Pharmaceutical Study on Total Alkaloids Suppiository,R283
  14. Study of a Gelrite/Alginate-based in Situ Gelling Ophthalmic Delivery System for Matrine,R283
  15. Clinical Study on Elderly COPD with Pulmonary Interstitial Fibrosis Treated by Bushenhuoxue,R259
  16. Connective Tissue Growth Factor, Nuclear Transcription Factor in Diabetic Rat Lung and the Intervention of Matrine,R285.5
  17. Study on Digitized Fingerprints of Radix Sophorae Flavescentis,R284
  18. Acupuncture combined with dialectical theory of governance Hunt Syndrome,R246
  19. Matrine Attenuates Pulmonary Arterial Hypertension Via Regulation ADMA/DDAH2 Signal Pathway and the Expression of eNOS,R285
  20. Preventive Effects of Matrine on Ventricular Remodeling of Chronic Heart Failure Rats and Its Molecular Mechanism,R285.5

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology
© 2012 www.DissertationTopic.Net  Mobile