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Effects of Unilateral Labyrinthectomy on GABAA Receptor Subunit Expression in the Rat Vestibular Nucleus and Floccular

Author: Liu
Tutor: KongWeiJia
School: Huazhong University of Science and Technology
Course: Otorhinolaryngology
Keywords: Vestibular nuclear complex Vestibular compensation γ-aminobutyric acid A receptor Rats Pompon
CLC: R764
Type: Master's thesis
Year: 2008
Downloads: 20
Quote: 0
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Abstract


Objective To observe unilateral labyrinthectomy postoperative rat vestibular nerve nuclear complex in vivo γ-aminobutyric acid A receptor α3 , β1 , δ subtype expression changes . Methods Adult male Wistar rats were divided into a the labyrinthectomy group of ( 18 ) and the control group ( 6 ) , the former destruction unilateral labyrinthectomy surgery in the control group the same way , but keep getting lost in good condition . After unilateral labyrinthectomy by immunohistochemistry , Western blot method to detect different survival time ( one day after 3 days, 7 days) group animals vestibular nerve composite body γ-aminobutyric acid A receptor α3 , β1 δ isoforms change . Results After 1 day , 3 days , 7 days groups on both sides of comparison and one day after the three days , seven days group compared with control group differences were not statistically significant . Conclusion early in the vestibular compensation , vestibular nerve the composite body γ-aminobutyric acid A receptor α3 , β1 , δ subtype expression changes most likely not involved in vestibular compensation . Objective To observe unilateral after labyrinthectomy rat cerebellar the pompon within γ-aminobutyric acid A receptor α3 , β1 , δ subtype expression changes . Methods Adult male Wistar rats were divided into a the labyrinthectomy group of ( 18 ) and the control group ( 6 ) , the former destruction unilateral labyrinthectomy surgery in the control group the same way , but keep getting lost in good condition . After unilateral labyrinthectomy , detected by immunohistochemistry survival time ( after 1 day , 3 days , 7 days ) group of animals within the cerebellar flocculus γ-aminobutyric acid A receptor α3, β1, δ subtypes expression changes . Results after unilateral labyrinthectomy gamma - aminobutyric acid A receptor β1 - induced cerebellar flocculus within the operative side δ subtypes increase up to one day after surgery , After 3-7 days in a downward trend , the seventh day and control The group expressed no difference . α3 subtypes weak staining in cerebellar flocculus . Groups on both sides of comparison and postoperative 1 day, 3 days , 7 days group compared with the control group showed no significant difference. Conclusion Unilateral labyrinthectomy induced the pompon γ- aminobutyric acid A receptor β1 , δ subtype increase . Balance the the bilateral vestibular central nervous resting discharge may be associated with the gamma - aminobutyric acid A receptor β1 , δ subtypes increase related to the increase within the pompon , but its role in vestibular compensation has yet to be studied . γ-aminobutyric acid A receptor α3 subtype expression in cerebellar flocculus weak , suggesting that α3 subtypes are not γ-aminobutyric acid A receptor structure and function of subtypes in the cerebellar flocculus .

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