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Expression Change of GABAA Receptor Subunits and Muscarinic Receptor Subunits in Rat Medial Vestibular Nucleus and Expression Change of Muscarinic Receptor Subunits in Rat Flocculus after Unilateral Labyrinthectomy

Author: ZouYu
Tutor: KongWeiJia
School: Huazhong University of Science and Technology
Course: Otorhinolaryngology
Keywords: Medial vestibular nucleus Vestibular compensation γ-aminobutyric acid A receptor Muscarinic receptors Pompon
CLC: R764
Type: PhD thesis
Year: 2007
Downloads: 17
Quote: 0
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Abstract


Change the purpose of the first part of the unilateral labyrinthectomy after γ-aminobutyric acid A receptor subtypes in the rat medial vestibular nucleus observed the left labyrinthectomy postoperative rat medial vestibular nuclear (medial vestibular nuclei MVN) within γ-aminobutyric acid A receptor (gamma-aminobutyric acid A receptor, the GABAA receptor) α1, β2, γ2 isoforms change. Using immunohistochemistry and in situ hybridization histochemistry, protein blotting, RT-PCR method, one side of the rat remnant labyrinth, observe the medial vestibular nucleus of GABAA receptor α1, β2, the γ2 subtype expression changes, and its possible role in vestibular compensation. The results of surgery on both sides of comparison and postoperative 1 day, 3 days, 7 days group differences were not significant compared with the sham group. Conclusion in early vestibular compensation GABAA receptor α1, β2, γ2 subtype expression changes most likely not involved in vestibular compensation. The second part of the unilateral labyrinthine resection muscarinic receptor subtypes in the rat medial vestibular nucleus Objective To observe the left labyrinthectomy postoperative rat medial vestibular nucleus (medial vestibular nuclei, MVN) within the muscarinic M1, M3, M5 subtypes of RyR expression changes. Method using immunohistochemistry, RT-PCR method, the removal of the rat unilateral labyrinthectomy observed medial vestibular nucleus muscarinic receptors M1, M3, M5 subtype expression changes vestibular compensation may role. After unilateral labyrinthectomy (UL), can induce bilateral MVN, muscarinic receptors M1, M3, M5 subtype reduce, one day after at least on an upward trend, After 3-7 days, 7 days and false The surgery group was no difference. Surgery on both sides, there were no differences. Conclusion can induce UL MVN muscarinic receptor M1, M3, M5 subtypes reduce. Vestibular central neurons resting discharge lowering may muscarinic receptors M1, M3, M5 subtypes in MVN decrease of unilateral labyrinthectomy but its role in vestibular compensation has yet to be the third part of the study? The changes after muscarinic receptor subtypes in the rat cerebellar flocculus purpose observe the left labyrinthectomy postoperative rat cerebellar flocculus within the muscarinic receptor M1, M3, M5 subtype expression changes. Method using RT-PCR method, the removal of the unilateral labyrinthectomy in rats, observed the cerebellar flocculus muscarinic receptors M1, M3, M5 subtype expression changes, its possible role in vestibular compensation. After unilateral labyrinthectomy (UL) induced bilateral pompon muscarinic receptors M1, M3, M5 subtype reduce, one day after at least on an upward trend, After 3-7 days, 7 days and sham group was no difference. Surgery on both sides, there were no differences. Conclusion UL After induced Pompon muscarinic receptors M1, M3, and M5 subtypes reduce. Vestibular central neurons the resting discharge reduction may muscarinic receptors M1, M3, M5 subtypes in pompon within reduce related, but its role in vestibular compensation has yet to be studied?

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