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The Relationship between Different Degree of Transcatheter Artery Embolization (TACE) for Primary Hepatic Carcinoma (PHC) in Patients and Serum Vascular Endothelial Growth Factor(VEGF) Content Changes

Author: ZhangFuQiang
Tutor: LiYuWei
School: Luzhou Medical College
Course: Medical Imaging and Nuclear Medicine
Keywords: Liver Cancer / Primary Chemoembolization Degree Vascular endothelial growth factor
CLC: R735.7
Type: Master's thesis
Year: 2009
Downloads: 30
Quote: 0
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Abstract


Objective: To study the different degree of hepatic arterial embolization of vascular endothelial growth factor (VEGF) content in the serum of patients with primary liver cancer (primary hepatocellular carcinoma PHC), to provide more evidence for clinical treatment. Methods: extract transcatheter arterial chemoembolization (TACE) before surgery, after 3,7 days by collecting 36 patients with previously untreated patients with primary liver cancer (massive), January (28-42 days) morning fasting cubital vein. Blood (without any anticoagulant), after serum obtained after centrifugation placed -200 refrigerator preservation, while withdrawing the normal serum control. The group collected 36 patients with primary liver cancer patients. Of 36 patients with obvious cirrhosis 16 cases, 20 cases no obvious cirrhosis; the of AFP gt; The at 1000ng/ml in 16 patients, AFP lt; 300ng/ml were eight cases at 1000ng/ml gt; the of AFP gt; the 300ng/ml those 12 cases; the tumor diameter gt; 10 cases 10cm diameter 5cm-10cm in 20 cases, the diameter lt; 5cm six cases; younger than the 40-year-old, 40-70-year-old 18 cases, more than 70 years old, 12 cases; including pseudocapsule 14 cases of non-enveloped 22 cases; liver cancer staging for the six cases of the Phase I, II, and 22 cases of III 8 cases; Pugh Class A 33 cases, three cases of grade B The all specimens ELSIA law focus on the detection of serum vascular endothelial growth factor content. The degree of liver lesions embolism postoperative hepatic angiography (DSA) image evaluation criteria. The measured values ??are (X | - ± S) P lt; 0.05 was considered statistically significant in all groups univariate analysis of variance was used to compare the pairwise comparison method (one-way ANOVA) diversity of the mean ( LSD method) or T-test. All statistical methods application to complete the SPSS14.0 professional statistical analysis software. Results: A total of 36 patients with primary liver cancer patients, which completely embolism 10 cases, most of the embolization of 16 cases, 10 cases of a small part embolism. Normal human serum VEGF levels of 146.91 ± 61.96 (ng / ml), lower than in patients with liver cancer group, the difference was statistically significant (P lt; 0.05 (), P = 0.041). 10 cases of complete occlusion in 36 patients, preoperative VEGF levels to 210.21 ± 98.06 (ng / ml), 3,7 days after the Jan. content is 267.49 ± 89.83 (ng / ml), 348.07 ± 140.60 (ng / ml), 199.07 ± 50.71 (ng / ml), the complete embolization group preoperative and postoperative three days in January, showed no statistical significance (P gt; 0.05) (P = 0.378; 0.862), and 7 days after The difference was statistically significant (P lt; 0.05) (P = 0.044); 7 days after the Jan. differences statistically significant (P lt; 0.05) (P = 0.031). Most of the embolization group and 16 cases, preoperative VEGF levels 266.97 ± 78.25 (ng / ml), after 3 days, 7 days Jan. content were 362.38 ± 46.51 (ng / ml), 273.54 ± 60.18 (ng / ml ), 327.79 ± 122.72 (ng / ml); most of the embolization group preoperative and postoperative three days the difference was statistically significant (P lt; 0.05) (P = 0.040), and 7 days after Jan. difference not statistically significant (P gt; 0.05) (P = 0.882,0.179); postoperative time points pairwise comparisons showed no statistical significance (P gt; 0.05) (P = 0.054) (P = 0.438) (P = 0.228); the small part embolism 10 cases, preoperative VEGF levels of 357.06 ± 147.19 (ng / ml), 3,7 days after Jan. content were 259.96 ± 72.01 (ng / ml), 288.54 ± 48.60 (ng / ml), 486.41 ± 65.59 (ng / ml), a small part of the preoperative embolization group and after 3 days, after 7 difference between statistical significance (P gt; 0.05) (P = 0.063,0.219), preoperative and after 1 month the difference was statistically significant (P lt; 0.05) (P = 0.026); after 3 days and 7 days after the difference was not statistically significance (P gt; 0.05) (P = 0.482), intraoperative after 3 days and after 1 month difference was statistically significant (P lt; 0.05) (P = 0.000). VEGF in the blood of patients with hepatocellular carcinoma and the patient's age, AFP, cirrhosis without statistical significance (P gt; 0.05), tumor stage was statistically significant (P gt; 0.05); tumor diameter: diameter lt; 5cm 5-10cm in diameter, the difference was not statistically significant (P gt; 0.05) (P = 0.141), diameter lt; a 5cm diameter gt; 10cm difference had statistical significance (P lt; 0.05) (P = 0.018). ; whether the pseudocapsule preoperative difference had no statistical significance (P gt; 0.05) (P = 0.092), postoperative difference was statistically significant (P lt; 0.05) (P = 0.000); presence or absence of metastases between difference was statistically significant (P lt; 0.05) (P = 0.014). Conclusion: massive liver cancer patients serum vascular endothelial growth factor (VEGF) content is higher than the normal control group; preoperative patient age, AFP, lesions whether the pseudocapsule, cirrhosis, and tumor clinical stage, lesion diameter metastasis-related; related to the extent of occlusion, the the different embolic degree of postoperative serum VEGF changes, the complete embolization Serum VEGF gradually increased after January decline; most embolization serum VEGF in short-term within decreased, January increased; small part of embolization serum VEGF in three days down, and then gradually increased.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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