Dissertation > Excellent graduate degree dissertation topics show

Comparison of Tissue Angiotensin Ⅱ in Atherosclerotic between Proximal and Distal Sites of Aortic Constriction in Rabbit

Author: ZhaoSheng
Tutor: LiuFuYuan
School: Anhui Medical University,
Course: Internal Medicine
Keywords: High cholesterol Coarctation Artery Atherosclerosis Hypertension
CLC: R543.5
Type: Master's thesis
Year: 2009
Downloads: 28
Quote: 0
Read: Download Dissertation

Abstract


Objective: To investigate the changes in atherosclerotic rabbit abdominal aortic surgery after high-fat feeding narrowing the proximal and distal vascular smooth muscle cells and tissue angiotensin II (Ang II). METHODS: New Zealand white rabbits were randomly divided into normal group, high-fat group after 28 weeks of feeding, the two groups were randomly selected part of the abdominal aorta constriction, the rest of sham-operated. Thus divided into fat-operated group, high-fat sham operation group, operation group, sham-operated group. To continue to raise after 4 weeks, blood samples measured blood lipids. Obtain specimens measuring abdominal coarctation of the aorta proximal and distal vascular pressure. HE staining intimal media thickness, immunohistochemical analysis detected endometrial, film alpha-muscle actin and angiotensin II levels. Results: 1 high-fat group compared with the normal group, TC (23.03 ± 2.62:1.95 ± 0.14), TG (4.77 ± 0.81:1.48 ± 0.27), LDL (10.73 ± 1.12:1.75 ± 0.56) were significantly increased, p lt; 0.05; the ordinary surgery group and the fat surgery group blood vessels to narrow the proximal blood pressure than the remote, general surgery group (72.30 ± 13.40:54.10 ± 11.00), high-fat surgery group (84.18 ± 5.28:52.62 ± 5.90), p lt; 0.01; 3 fat hand group and high-fat sham operation group narrowing the film thickness in the proximal than the remote, high-fat sham operation group (154.04 ± 3.22:136.13 ± 4.30), fat operation group (174.42 ± 7.83:128.35 ± 8.13), p lt; 0.05, higher fat surgery group fat sham operation group narrow the proximal end of the film thickness increase (174.42 ± 7.83:154.04 ± 3.22), p lt; 0.05; 4 endometrial thickness: fat surgery group narrowed proximal than distal thickening (183.76 for ± 10.53:118.63 ± 13.35), p lt; 0.01; the fat surgery group constriction proximal higher fat the same location of the sham-operated group thickening (183.76 for ± 10.53:164.59 ± 4.96), p lt; 0.01; 5.α-actin levels: the intima, high fat surgery group narrowed proximal than narrowing the remote was significantly higher (0.13 ± 0.01: 0.08 ± 0.01), p lt; 0.01; the fat surgery group coarctation proximal higher fat sham operation group the narrow proximal significantly increased (0.13 ± 0.01:0.10 ± 0.02), p lt; 0.01; in the film, shrink The narrow proximal remote, but the surgery group (0.10 ± 0.03:0.08 ± 0.03), p gt; 0.05, fat-operated group (0.23 ± 0.04:0.15 ± 0.02) p lt; 0.05; fat surgery group reduction The narrow proximal higher fat sham group and the surgery group coarctation proximal pressure p lt; 0.05; 6.Ang level II: endometrial, high fat surgery group narrowed proximal than narrowing the remote was significantly higher ( 0.26 ± 0.01:0.12 ± 0.01), p lt; 0.01; higher fat surgery group narrowed proximal fat sham operation group was significantly higher (0.26 ± 0.01:0.17 ± 0.01), p lt; 0.01; in the film, shrink The narrow proximal remote, but the surgery group (0.11 ± 0.01:0.08 ± 0.02), p gt; 0.05, high-fat surgery group (0.28 ± 0.04:0.16 ± 0.02) p lt; 0.05; the fat surgery group shrink The narrow proximal higher fat sham group and operation group to narrow proximal elevated p lt; 0.05. Conclusion: simple rabbit abdominal aortic coarctation after 4 weeks, the narrow nearly caused - Remote pressure difference, can not lead to arterial intimal thickening the alpha actin protein, vascular tissue Ang Ⅱ. Only under the influence of high-fat high-pressure, blood vessel constriction proximal intima-media than the constrictive remote thickening tissue Ang II levels increased.

Related Dissertations

  1. Serum A-FABP Levels and Its Expression in Atherosclerotic Plaques of Diabetes Mellitus,R587.1
  2. Isolated systolic hypertension in patients with cardiac ultrasound characteristics of traditional Chinese medicine dialectical correlation exploration,R544.1
  3. Integrative treatment of elderly patients with hypertension TCM syndromes and quality of life,R544.1
  4. The Changes of Intimal Macrophages, Smooth Muscle Cells, Collagen, and Cpt-Ⅰ, GLUT-4 of Vascular Media in Human Lower Limb Artery with Atherosclerotic Stenosis,R543.5
  5. Effect of High Glucose on Chemokine Ligand 16 (CXCL16) Expression and Secretion in THP-1 Macrophages and Intervention of Aspirin in the Activity,R587.2
  6. Association between Microalbuminuria and Cardiovascular Events in the Patients with Primary Hypertension,R544.1
  7. Correlation Research of Plasma Apolipoprotein CⅢ and High Sensitive C-reactive Protein with Atherothrombotic Cerebral Infarction,R743.33
  8. Dual-source CT in the Diagnosis of Coronary Artery Stenosis: a Meta Analysis,R541.4
  9. In Vitro Culture and Identification of Vascular Smooth Muscle Cells from Rat Intra- and Extracranial Arteries,R743.3
  10. The Effect of P-selectin on the Maturation of Dendritic Cells from Human Peripheral Blood,R543.5
  11. The Effects and Mechanism of Cellular Repressor of ELA-stimulated Genes on Pathological Vascular Endothelium Apoptosis,R363
  12. Carotid Artery Wall Elasticity and Carotid Atherosclerosis in Diabetes Mellitus Patients with Microalbuminuria Using Ultrasonographic Elastography and High-freguency Ultrasound,R445.1
  13. In Vitro State the Experiment Study of the Arterial Blood Gas Level and the Arterial Thrombus Volume by MRI,R445.2
  14. Study on Knowledge, Attitude, and Behavior to Calcium Nutrition Among Patients with Hypertension in a Community,R473.2
  15. Correlative Study on Plasma Level of Resistin in Patients with Coronary Atherosclerosis Disease,R541.4
  16. Evaluation of Left Ventricular Radial and Axis Systolic Function in Patients with Essential Hypertention Using Two-dimensional Speckle Tracking Imaging,R541.3
  17. Heterogeneity and Meta Analysis of the Essential Hypertension Risk Assessments,R544.1
  18. Evaluation of Right Ventricular Function in Patients with Hypertension Without Left Ventricular Remodeling by Tei Index, Two-dimensional Strain and Quantitative Tissue Velocity Imaging,R541.3
  19. Experimental Study on Antiatherosclerosis with EL Antisense,R543.5
  20. Effects of High-salt Dieet on Blood Pressure and the Remodeling of Carotid Arteries and the Intervention of Telmisartan in Wistar Rats,R544.1
  21. Serum Levels of Insulin Like Growth Factor-1 and Cardiovascular Remodeling in Patients with Hypertension,R544.1

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Vascular disease > Artery disease
© 2012 www.DissertationTopic.Net  Mobile