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Expression and Significance of Smac and Survivin in Cervical Squamous Carcinima

Author: ZuoChunMei
Tutor: YangYongXiu
School: Lanzhou University
Course: Obstetrics and Gynaecology
Keywords: The second mitochondrial sources cysteine ??aspartic proteolytic enzyme activator Survivin Cervical Cancer Apoptosis Immunohistochemistry
CLC: R737.33
Type: Master's thesis
Year: 2009
Downloads: 53
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Abstract


Objective To observe the second mitochondrial source of cervical squamous cell carcinoma of the cysteine ??protease activator (Smac) and survivin (survivin) expression in normal cervical tissue and cervical squamous cell carcinoma and explore its clinical significance . Methods Immunohistochemical SP method detected 70 cases of cervical squamous cell carcinoma and 11 cases of normal cervical tissue of Smac survivin protein expression , and to analyze the relationship between cervical squamous clinicopathological factors . Results Smac protein is not expressed in normal cervical tissue and 70 cases of cervical squamous cell carcinoma in 35 cases (50%) express positive, I , Ⅱ Phase III cervical squamous cell carcinoma of the positive expression rate was 80.95 %, 50% and 19.04% , respectively , the difference was statistically significant ( P <0.05 ) . Smac protein expression in cervical squamous cell carcinoma with pathological grade , lymph node metastasis . Survivin protein expression in normal cervical tissue , expression was positive in 38 cases ( 54.29% ) of 70 cases of cervical squamous cell carcinoma , including pathological grade G 1 grade the G 2 to 3 < survivin protein in cervical squamous cell carcinoma of the class / sub> positive rate was 27.27% ( 3 / 11 ) and 59.32% ( 35 / 59 ) , the difference was statistically significant ( P <0.05 ) . Clinical stage Ⅰ ~ Ⅱ and Ⅲ cervical squamous cell carcinoma the survivin positive rate of 52.5% and 80.96% , the difference was statistically significant ( P <0.05 ) . The survivin protein positive expression rate of cervical squamous cell carcinoma pathological grade and clinical stage were positively correlated (r = 0.328,0.345 , P <0.05 ) . Smac and survivin gene expression levels in cervical squamous cell carcinoma was negatively correlated (r = -0.236, P = 0.016). Conclusion 1. Cervical squamous cell carcinoma of Smac, survivin protein expression increased, may be involved in abnormal cell proliferation and apoptosis imbalance results ; 2.Smac expression in cervical cancer is a frequent event , by inhibiting Survivin promote apoptosis , its expression and Survivin was a negative correlation , both possible cervical cancer cell apoptosis signaling network .

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Uterine tumors
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