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5 - serotonin transporter promoter CpG island methylation and correlation analysis of the cause of schizophrenia

Author: DongYan
Tutor: BaiYan；ChengYuZuo；XuXiuFeng
School: Kunming Medical College
Course: Psychiatry and Mental Health
Keywords: DNA methylation Schizophrenia 5 - serotonin transporter Bisulfite sequencing
CLC: R749.3
Type: Master's thesis
Year: 2010
Downloads: 84
Quote: 0
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Abstract


Background The incidence of schizophrenia in the world is about 1 %, has Reference 5 - hydroxytryptamine (5-hydrotryptamine ,5-HT) dysfunction , including schizophrenia , including several with mental disorders. 5 - serotonin transporter (Serotonin transport ,5-HTT) by determining synaptic 5-HT signal strength and duration of the five - the neurotransmitter serotonin can play a key role . Recent studies have shown that 5-HTT promoter CpG island methylation is associated with mRNA transcripts methylation ,5-HTT 5-HT function is an important regulator of factors . Therefore, we have reason to believe that 5-HTT promoter CpG island methylation is associated with schizophrenia . Quantitative analysis of schizophrenia Objective 5 - serotonin transporter promoter CpG island methylation level Analysis 5 - serotonin transporter promoter CpG island methylation levels and the relationship between schizophrenia etiology . Methods 30 patients with primary schizophrenia , take their blood , the application of sodium bisulfite sequencing (bisulfite genomic sequencing, BSP) Detect 5 - serotonin transporter promoter CpG island methylation of CpG sites condition . Results The patient group and the normal control group 5-HTT gene promoter CpG island methylation levels were not statistically significant χ2 = 0.61, P gt; 0.05; 18-27 age group χ2 = 1.00, P gt; 0.05,28 -42 age group χ2 = 0.52, P gt; 0.05, methylation level and age difference was not statistically significant ; men methylation levels χ2 = 0.25, P gt; 0.05; female methylation levels χ2 = 0.26, P gt; 0.05, methylation levels and gender difference was not statistically significant. Conclusion 5-HTT gene promoter CpG island methylation levels in schizophrenia and normal control group no significant difference between the groups ,5-HTT gene promoter CpG island methylation levels may not be related to the onset of schizophrenia factor.

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CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Schizophrenia
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