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Objective To investigate the CC chemokine receptor 5 (CCR5, CC chemokine receptor 5) gene promoter region 59029G / A polymorphism and Chinese Yunnan Lincang Wa impaired glucose regulation (IGR) correlation. Methods Chinese Yunnan Lincang Wa glucose screening populations 109 cases of impaired glucose regulation (IGR) - simply adjust impaired fasting glucose (IFG) in 96 cases of isolated impaired glucose tolerance (IGT) in 7 patients, both IFG and IGT (IFG IGT) in 6 patients as IGR group and 60 healthy subjects as normal control (NC) group, using the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) technique, on the above population CCR5 gene promoter region 59029G / A polymorphisms were detected and comparative analysis among groups genotype and allele frequencies and associated clinical data. Results (1) IGR group, age, waist-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), serum albumin (ALB), serum total protein (STP), aspartate aminotransferase (AST), total cholesterol (TC) higher than NC group (P lt; 0.05), NC group of alanine aminotransferase (ALT), creatinine (CREA) higher than the IGR group (P lt ; 0.05). The remaining clinical and biochemical parameters in different no statistically significant difference between the groups (P gt; 0.05). (2) IGR in blood pressure than the number of NC group (X2 = 14.113, p = 0.000 lt; 0.05). (3) NC and genotype frequencies between IGR group (X2 = 1.403, p = 0.496 lt; 0.05) and allele frequencies (X2 = 0.059p = 0.809 gt; 0.05) was not statistically different. (4) IGR groups of different genotypes, GA genotype GG genotype than ALT (P = 0.039), GA genotype TC than GG, AA genotype (P = 0.000, P = 0.024). The remaining clinical parameters were not statistically different. (5) Logistic regression analysis showed that: the age, SBP, WHR, LDL is a risk factor for impaired glucose regulation, SUA was negatively correlated with IGR (partial correlation coefficient r = 0.012, P = 0.03 lt; 0.05). Conclusion Chinese Yunnan Lincang area Wa people, CCR5 gene promoter region 59029G / A polymorphism may be associated with IGR no correlation, and is not IGR risk factors; Age, SBP, WHR, LDL is a risk factor for IGR. Objective To investigate the CC chemokine receptor 5 (CCR5, CC chemokine receptor 5) gene promoter region 59029G / A polymorphism in Chinese Han people and the Yunnan region exists between Wa heterogeneity. Method before Han population and population studies Wa, select Chinese Yunnan Han nationality 60 cases (39 males, 21 females) and 60 cases of normal population Wa (24 males, 36 females), comparative analysis of the groups CCR5 gene promoter region 59029G / A polymorphism genotype and allele frequencies. Results (1) Han and Wa genotype frequencies are not the same, the difference was statistically significant (X2 = 11.157, p = 0.04 lt; 0.05); Wa G / A, A / A genotype frequencies higher than the Han (X2 = 49.36, p = 0.000 lt; 0.05, X2 = 33.29, p = 0.000 lt; 0.05); G / G genotype frequencies below the Han (x2 = 33.29, p = 0.000 lt; 0.05). (2) two alleles were significantly different between races (X2 = 154.18, p = 0.000 lt; 0.05). Conclusion Yunnan Han population and Wa crowd CCR5 promoter 59029G / A polymorphism genotype frequency distribution may be different; Wa groups G / A, A / A genotype and A allele frequency may be higher than the Han crowd.
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