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Solanum nigrum (Solanum nigrum L.) the Solanaceae (Solanaceace) solanaceous plants, also known as wild grape, the crows eyes grass, bitter herbs, bitter Kwai, one to perennial herb, are distributed throughout the country. Solanum nigrum whole plant can be used as medicine, The modern pharmacological prove Solanum nigrum has anti-tumor, anti-inflammatory, anti-shock, anti-allergy, detoxification, expectorant cough, blood pressure and other effects. This study of the chemical composition of Solanum nigrum leaves and fruit and its main anti-tumor biological activity. Extraction, separation and purification, six compounds isolated from Solanum nigrum leaves, from dragon of Kwai Tsing fruit isolated three compounds. IR, UV, MS, one-dimensional and two-dimensional NMR spectral means analysis identified the structure of the nine ingredients. : 5 \u0026alpha;, 22α, 25R-26-O-beta-D - glucopyranosyl -22 - methoxy - Furostanol-3beta, 26 - diol-3-O - beta-D - glucopyranosyl group - (1 → 2)-O - [beta-D - xylopyranosyl group - (1 → 3)]-O-beta-D - glucopyranosyl - (1 → 4)-O-beta-D - galactopyranoside (the compound L1); 5 \u0026alpha;, 22α, 22R-26-O-beta-D - glucopyranosyl group -22 - hydroxy - Furostanol-3beta, 26 - diol-3-O-beta-D - glucopyranosyl - (1 → 2)-O - [beta-D - xylopyranosyl group - (1 → 3)]-O-beta-D - glucopyranosyl group - (1 → 4)-O -beta-D - galactopyranoside (Compound L2); Australia eggplant section the alkali (Compound L3); 5a, 22α, 25R -12 - carbonyl - 22 - hydroxy - Furostanol -26 - carboxy-3-O- - (1 → 4)-O-beta-D - glucopyranosyl-(1 → 4)-O-beta-D - glucopyranosyl - (1 → 2)-O-β-D - glucopyranosyl- beta-D - galactopyranoside (Compound L5); quercetin-3-O-alpha-L-rhamnose group - (1 → 4)-O-beta-D-glucose group - (1 → 6 )-O-beta-D-glucoside (compound L6); 5a, 25R-spirostan - 3-O-beta-D-xylopyranosyl - (1 → 3) - O-beta-D-pyran glucose group - (1 → 2)-O-beta-D-pyran-glucose group - (1 → 4)-O-beta-D - galactopyranoside (Compound L7); beta-sitosterol (compound L8) , daucosterol (compound L9) and quercetin (compound L10). Which L5, L6, L7 are first isolated from Solanum nigrum. This experiment also studied the chemical composition of Solanum nigrum anti-tumor biological activity of the different components group, the results show that the growth of total saponin of Solanum nigrum and Solanum nigrum alkaloids the mouse hepatoma H 22 and Lewis lung carcinoma showed some inhibition, and dose-dependent manner, the value of in-depth development and utilization. The results of the present study to clarify the material basis of Solanum nigrum biological activity, and provide a scientific basis to find new medical uses for Solanum nigrum grass.
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