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Design and Application of the Fluorescence BODIPY-based Sensors for Mercury

Author: WangZuo
Tutor: FanJiangLi
School: Dalian University of Technology
Course: Fine Chemicals
Keywords: Fluorescent probe Bodipy dyes Mercury ions Methylmercury Natural water Microscopic imaging Living cells
CLC: O614.243
Type: Master's thesis
Year: 2010
Downloads: 286
Quote: 0
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Abstract


Now, mercury-free products have depth all aspects of people's lives, thermometers, batteries, and other household items has become necessary for each family. However, the growing incidence of mercury pollution caused due to the incorrect use of the people or mishandling of mercury leaked. In addition, the volcanic eruption, the consumption of fossil fuels, especially the exploitation of the mine, causing varying degrees of mercury pollution, endangering the ecological environment and human health. More serious, the mercury in microbial methylation into methylmercury, it is one of the most toxic mercury species, can be hazardous to human health through the food chain, causing irreversible damage to the human central nervous system . Environmental and ecological issues makes the detection of various forms of mercury imminent. Recent analysis means to detect mercury significant development, spectrometry, chromatography instruments, together with technical, such as GC-MS, GC-ICP-MS and HPLC-ICP-MS has been widely adopted, but the complex process of sample pretreatment, detection time, the high cost of the further development of this method is always limited. Chemical sensors with high sensitivity, high selectivity, simple and rapid detection technology rapid development, more and more widely in the elemental analysis. Therefore, the use of fluorescent probes to detect various forms of mercury in vivo environment or life especially methylmercury, has become an important research topic in supramolecular chemistry as well as in the biomedical field. In this group work based on the design of a BODIPY fluorophore o-aminophenol to identify groups of mercury ion fluorescence probe B3. Ethanol-HEPES buffer solution B3 of mercury ions with good selectivity and high sensitivity can detect ppb levels of mercury ions. Importantly, the probes can be applied in real natural water samples to detect the sub-ppb levels of mercury ions. In addition, the probe B3 can be detected in the sulfur-rich environment of mercury ions and undisturbed, and mercury ions in living cells can be used for fluorescence imaging. Of the paper's groundbreaking design and synthesis of a specific identification of methylmercury, the mercury ion is not responding of methylmercury fluorescent probe B5. We first introduced in the B3 molecule methyl palladium complex design and synthesis of a mercury ion probe B4 ethanol - aqueous solution in two ways by UV and fluorescence selective recognition of mercury ions. Product of probe the B4 and mercury ions - palladium complexes B5 can be loyal to identify methylmercury in acetonitrile without mercury ion response is the first from the mercury ion interference the methylmercury fluorescent probe needle.

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CLC: > Mathematical sciences and chemical > Chemistry > Inorganic Chemistry > Metal elements and their compounds > Section II group metal element and its compounds > The zinc Vice family (Ⅱ B group metal elements ) > Mercury Hg
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