Dissertation > Excellent graduate degree dissertation topics show

Effect of Combined Application of Exemestane and Docetaxel on the Growth of Human Endometrial Carcinoma Xenografted Tumors in Nude Mice

Author: LvHongWei
Tutor: MaXiaoXin
School: China Medical University
Course: Obstetrics and Gynaecology
Keywords: Nude mice Endometrial carcinoma Exemestane Docetaxel
CLC: R737.33
Type: Master's thesis
Year: 2010
Downloads: 41
Quote: 0
Read: Download Dissertation

Abstract


ObjectiveTo observe the antitumor effect of combined application of exemestane and docetaxel on xenografted tumor growth of human endometrial carcinoma in nude mice and the molecular mechanism.MethodsHuman endometrial adenocarcinoma ishikawa cells were inoculated into athymic nude mice.Twenty-four nude mice bearing human endometrial carcinoma xenografted tumor were randomly divided into 4 groups (n=5 in each group),experiment group mice were selected to be treated with exemestane and/or docetaxel for three weeks,and control group mice were selected to be treated with 0.9% sodium chloride for three weeks. After that tumor volume was precisely measured,concurrently TUNEL was used to measure the effects of exemestane and docetaxel on cell apoptosis.ResultsCompared with the control group,the tumor growth inhibition rates were 25.59%,27.41% and 47.09% in exemestane group,docetaxel group and combined group,the latter of which was lower than that in exemestane group and docetaxel group (P<0.05).The apoptosis of endometrial carcinoma cells were induced by exemestane and docetaxel,the apoptosis rate reached to the peak when the cells were treated with exemestane combined docetaxel,compared with the control group,the apoptosis rates were (30.92±2.95)%,(32.65±2.72)% and (40.14±3.44)% in exemestane group,docetaxel group and combined group, the latter of which was lower than that in exemestane group and docetaxel group (P<0.05).ConclusionExemestane and Docetaxel can significantly inhibit the growth of human endometrial carcinoma xenografted tumors in nude mice,and their combination can produce a synergistic action.

Related Dissertations

  1. Study of Melittin on Tumor Inhibition and Part of Mechanism of Human Hepatocellular Carcinoma HepG-2 Xenograft in Nude Mice,R735.7
  2. Effect of β-elemene Combined with Radiotherapy on the Angiogenesis of Lung Adenocarcinoma Xenograft Tumor in Nude Mice,R734.2
  3. Clinical Observation Pemetrexed Combined with Cisplatin As First-line Treatment of Advanced Lung Adenocarcinoma,R734.2
  4. The Plumbagin in Combination with Docetaxel Inhibit Proliferation in Prostate Cancer Cells and Its Possible Mechanism,R737.25
  5. Value of the Ultrasound CT and MRI in Pre-operative Staging of Uterine Endometrial Carcinoma,R737.33
  6. 临床研究 Neo-adjuvant Docetaxel and Cisplatin Followed by Concurrent Docetaxel and Cisplatin with Intensity-modulated Radiation Therapy in Treatment of Locally Advanced Recurrent Nasopharynx Cancer,R739.63
  7. Animal and Clinical Studies of 18F-FDG PET-CT in Early Assessment of Radiotherapy Efficacy of Nasopharyngeal Carcinoma and the Correlation Analysis of Ki67 Expression,R739.63
  8. Descriptive Study of Railway Traffic Harm Accidents with Circular Distribution,R735.1
  9. Influence of Gonadotropin-releasing Hormone Agonist on the Effects of Chemotherapy Upon Ovarian Cancer and the Prevention of Chemotherapy-induced Ovarian Damage:an Experimental Study with Nu/nu Athymic Mice,R737.31
  10. Synergistic Augmentation of Cisplatin-induced Apoptosis in Hela Cells by Rapamycin,R737.33
  11. The Mechanism That Fangchinoline Inhibits Proliferation of PC-3 Cells,R737.25
  12. Expression and Significance of p-mTOR and p-P70S6K in Benign and Malignant Endometrical Diseases,R737.33
  13. Establishment of an Implanted Model of Human Gastrointestinal Stromal Tumors in Nude Mice and Observation Their Biological Characters,R735
  14. Reconstitution of T Cell-mediated Immune Function in Nu/nunude Mice by Cotransplantation of Human Thymus Tissue and Umbilical Cord Blood CD34~+ Hematopoietic Stem/progenitor Cells,R392
  15. The Synthesis of α-Asarone and Steroidal Drugs,TQ464
  16. The Study of Survivin Gene Expression and Apoptosis in Hep-2 Cell Induced by Docetaxel,R739.65
  17. Bifidobacterium Infantis as a Delivery System for Cancer Gene Therapy: Targeting Localization and Growth in Hypoxic Region of Tumors,R739.63
  18. Study on the Inhibition of Antisense Oligodeoxynucleotides Transfection on Expressions of Paxillin in Esophageal Carcinoma EC9706 Cells,R735.1
  19. IL-8 related to nude mice bearing human cancer model and IL-8 neutralizing antibody , IL-8 shRNA its influence tumor growth,R737.33
  20. Preliminary Studies on Nanostructured Lipid Carriers Loaded with Docetaxel,R944
  21. Efficacy and Safety of Fertility-sparing Treatment in Young Patients with Early Endometrial Cacinoma,R737.33

CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Uterine tumors
© 2012 www.DissertationTopic.Net  Mobile