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The Clinical and Experimental Observations of Resistance Strengthened & Pathogenic Wind Removed in Treatment of Allergic Rhinitis

Author: LuZhiFeng
Tutor: LiHao
School: Guangzhou University of Traditional Chinese Medicine
Course: TCM features science
Keywords: Allergic rhinitis Chinese medicine treatment Nasal secretions Substance P
CLC: R276.1
Type: Master's thesis
Year: 2010
Downloads: 56
Quote: 0
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Abstract


Purpose: This project director Lee observed to obtain satisfactory efficacy in clinical prescription coupon expelling particles self on allergic rhinitis (AR) and efficacy in patients with nasal secretions influence of substance P from the perspective of Neuroimmunology consolidate expelling particles effect mechanism, to improve the treatment of allergic rhinitis effect of Chinese medicine to provide new ideas, new prescriptions. Methods: In determining the allergic rhinitis diagnostic criteria, inclusion criteria, exclusion criteria and evaluation criteria, based on 100 patients compliant AR were randomly divided into treatment group and control group. Treatment group taking coupon expelling particles, each 10g, 2 times a day, after meals warm water. The control group received each time Yupingfeng particles 5g, 2 times a day, after meals warm water. Observed before and after treatment the patient's clinical symptoms, signs and nasal secretions substance P content changes. Results: 1 The clinical efficacy of Results: After treatment, significant efficiency 46%, efficiency of 28%, the total efficiency of 74%. After treatment, the efficiency of the control group were 24%, efficiency 44%, the total efficiency of 68%. 2, signs and symptoms after treatment than before treatment total score were significantly lower (P <0.05), total score of symptoms and signs in both groups compared with each other there was significant difference (P lt; 0.05), the treatment group compared with the control points significantly reduced. 3, the two groups before and after treatment of substance P in nasal secretions: before treatment to obtain nasal secretions volume of 1.42 ± 0.38ml, P substance content was 35.79 ± 10.03ng/mL, treatment of nasal secretions volume of 1.12 ± 0.29m1, P substance content was 27.51 ± 7.28 ng / mL; nasal secretions control group before treatment volume 1.38 ± 0.35m1, P substance content was 35.96 ± 11.73ng/mL, treatment of nasal secretions volume of 1.25 ± 0.34m1 , P substance content was 31.76 ± 9.17ng/mL. nasal secretions before treatment of substance P levels showed no significant difference in significance (P gt; 0.05), after a course of treatment, both groups nasal secretions Substance P content compared with their pre-treatment has significantly decreased, the difference was significant (P lt; 0.05), suggesting the two treatment regimens in patients with allergic rhinitis can reduce substance P levels in nasal secretions. Experimental group compared with the control group, can reduce levels of substance P (P lt; 0.05), prompted the experimental group was more better. Conclusions: The clinical studies showed that consolidate expelling particles symptoms and signs of improvement in the treatment group was significantly higher than that, you can more significantly reduce the SP content between the two groups was statistically significant (P lt; 0.05). Show consolidate Decoction by reducing the SP content, thereby reducing the number caused by the SP physiological and pathological reactions, allergic rhinitis have a better therapeutic effect.

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CLC: > Medicine, health > Chinese Medicine > Traditional Chinese Medicine ENT > Department of Otolaryngology,
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