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Vascular Endothelial Growth Factor (VEGF) in Congenital Heart Disease with Pulmonary Hypertension

Author: WangLiChun
Tutor: LvChaoXia
School: Dalian Medical University
Course: Internal Medicine
Keywords: Vascular endothelial growth factor Congenital heart disease Pulmonary hypertension
CLC: R541.1
Type: Master's thesis
Year: 2010
Downloads: 76
Quote: 0
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Abstract


Objective: line involved in the detection of different time periods before and after treatment of vascular endothelial growth factor (VEGF) in patients with congenital heart disease, congenital heart disease and pulmonary hypertension (PH) patients involved in the changes before and after treatment serum levels of VEGF and the VEGF PH formation and development of the relationship. Methods: successful line congenital heart disease interventional transcatheter therapy of 50 patients with atrial septal defect (ASD) 22 cases, ventricular septal defect (VSD) 11 cases, patent ductus arteriosus (PDA) 17 cases, including 24 males and female 26 cases. Age 9-54 (31.6 ± 11.58) years of age. Patients without intravenous anesthesia, hypertension, diabetes and heart failure, no liver and kidney dysfunction, cancer and other diseases, non-pregnancy and lactation. Surgery, right heart catheterization in patients with congenital heart disease, directly measured pulmonary pressures, superior vena cava, the inferior vena cava, right atrium, right ventricle, pulmonary artery and the femoral artery or left atrial blood gas analysis, calculation points traffic. Normal pulmonary artery pressure group (mPAP ≤ 25mmHg) 18 cases, mild pulmonary hypertension group (25 lt; mPAP ≤ 35mmHg) 20 patients with moderate to severe pulmonary hypertension group (mPAP gt; 35mmHg) 12. Three age groups and gender difference was not statistically significant (P gt; 0.05). Confirmed that the health of the normal control group (15 males and 27 cases of examination centers; 12 females), aged 21-53 (29.0 ± 9.7) years old. Patients before the intervention, after 1 hour, blood samples after 24 hours and 30 days after surgery. The blood samples were extracted outer peripheral blood 2ml, serum separation tube for collecting blood samples, agglutination immediately centrifuged after 30 minutes (1000g x 15 minutes) and serum was separated. Blood serum in Eppendorf tubes, placed in a -70 ° C freezer refrigerators to be tested, measured using a double antibody sandwich ABC-ELISA method of vascular endothelial growth factor. Kit on Haixi Tang biotechnology company. Statistical Methods: spss for windows 17 statistical software analysis and processing, experimental All data are expressed as mean ± standard deviation (x ± s). Between the case and control groups and between the same group using t test among the three groups and the control group difference was significant using analysis of variance, P lt; 0.05 indicated significant difference. VEGF levels and pulmonary artery pressure, left to right shunt flow intercropping statistical analysis. Results: normal pulmonary artery pressure groups (105.06 ± 56.060pg/ml) with the control group (75.90 ± 52.833pg/ml) significant difference (P gt; 0.05); pulmonary hypertension group than in the control group were statistically differences, namely light the degree of pulmonary hypertension group (134.32 ± 57.82pg/ml) higher than that of the control group (75.90 ± 52.833pg/ml) was statistically significant (P lt; 0.05), and significantly higher in severe pulmonary hypertension group (193.36 ± 61.51pg/ml) in the control group (75.90 ± 52.83pg/ml) was statistically significant (P lt; 0.01); intervene in one hour and 24 hours after closure was no significant difference (P gt; 0.05), 30 days after plugging surgery before significant difference (P lt; 0.01); correlation analysis showed that serum VEGF levels with congenital heart left to right shunt flow was positively correlated with pulmonary artery pressure was positively correlated. Conclusion: CHD patients with left-to-right shunt, the of VEGF measured values ??and PH level was positively correlated, suggesting that VEGF plays an important role of mediated process caused by congenital heart disease, pulmonary vascular remodeling PH. 2.CHD patients with left-to-right points the greater the flow, the more obvious VEGF levels increased, increased pulmonary blood flow is an important factor to cause PH. 24 hours after VEGF by 3.CHD closure began to decline, particularly evident a month later, VEGF reversible congenital cardiac interventional therapy can effectively improve the PH, pulmonary artery pressure recovery may take longer.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Congenital heart disease
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