Dissertation > Excellent graduate degree dissertation topics show

Inflammatory damage in chronic alcoholism on the cardiovascular system

Author: KangChengFang
Tutor: LvJiYuan
School: Shanxi Medical
Course: Internal Medicine
Keywords: alcohol interleukine-1β vitamineC taurine
CLC: R595.6
Type: Master's thesis
Year: 2010
Downloads: 66
Quote: 0
Read: Download Dissertation

Abstract


Background:At present, alcoholic beverages can be seen from time to time and can be seen everywhere, ever since human beings have been documented, alcoholic beverages had been associated with the history of mankind civilized. However, with the level of human science and technology advances, more and more evidence that:alcohol given people better sensory enjoyment, also caused tremendous damage to the body, especially in the cardiovascular system, its injury is more prominent. As we all know, cardiovascular disease is the number one killer of today’s human death, then how much alcohol can cause changes in the cardiovascular system and what changes? With that issue in-depth study,Is bound to the human eye toward the issue deeper.Objective: To reveal the protective effect of vitamin C and taurine of chronic alcoholism, IL-1 and IL-6 changesMethods:80 healthy male Wistar rats were officially observed in the laboratory prior to testing, the normal feeding rats a week, including a daily record of each animal’s food and water consumption. A week later experimental groups:blank control 16; alcohol group 16; alcohol+ taurine group 16; alcohol+Vitamin C16 only; alcohol+Vitamin C+Taurine 16 built a model of chronic alcohol consumption for 20 weeks. Modeling methods:in drinking water by adding 2-4g /(kg·d); with the TAU methods:in drinking water by adding TAU2%. Measurement of body weight once a week; food consumption once a day; animals were killed at the 20th weekend,indicators of the serum for testing.Results:1 interleukin-1βtest results of the blank control group (0.0586±0.0037) compared with rats of alcohol serum IL-1(0.2930±0.0088)significantly increased the OD value difference was statistically significant (P<0.05).. Compared with alcohol, alcohol+taurine group (0.1548±0.0069); ethanol+vitamin C group (0.1956±0.0075); alcohol+taurine+vitamin C group (0.0860±0.0075) three groups of interleukin 1βOD values of a much lower level, the difference was statistically significant (P<0.05).. Taurine+vitamin C group synergy of interleukin-1βlevels were somewhat lower (P<0.05).2 Interleukin-6 test results and interleukin-1 have similar statistical findings that vitamin C+taurine group of the lowest concentration,alcohol group of the highest, but were higher than the control group (0.0547±0.0017), the difference statistically significant (P<0.05)..Conclusion: Compared with the control group, alcohol group of IL-1βand interleukin-6 serum levels were significantly higher, that ethanol group compared with the strong inflammatory response. At the same time with vitamin C or taurine plus group of two kinds of inflammatory mediators in the serum concentration is much smaller, that vitamin C and taurine on the cardiovascular system protection. At the same time combined with vitamin C and taurine group of the two lowest concentrations of inflammatory mediators, indicating both combined use of alcohol-induced damage to the cardiovascular system, the strongest protective effect.

Related Dissertations

  1. Haihong Fruit Vinegar Processing Technology,TS264.22
  2. Study on Using Sepiolite As Supported Catalysts in Selective Hydrogenation of Cinnamaldehyde to Cinnamyl Alcohol,O643.32
  3. Modification for PVA-Based Composite Packaging Material with Nano-SiO2 and Its Influence on Fresh Preservation Effect of Salted Duck Eggs,TS253.46
  4. Non-contact Theoretical Analysis of the Measurement Technology for Detecting the Alcohol Content in Blood Using Raman Spectroscopy,U492.8
  5. Studies on the Extraction of Total Flavonoids from Momordica Charantia L. and the Production of Alcohol by By-product,TQ914.1
  6. Effect of Alcohol on Attention Using Attention Network Test,B841
  7. Study on Dehydration of tert-Butyl Alcohol Catalyzed by Functionalized Ionic Liquid,O643.32
  8. The Protective Effect of Taurine on Alcoholic Brian Damage in Rats,R595.6
  9. Study on Supramolecular Effect of Cyclodextrin and Alcohol System,O641.3
  10. Designed and Advanced Control Strategy Implement of DCS Base on PCS7 PVA Production Process,TP273
  11. Taurine and L-carnitine Synergistically Inhibit the Proliferation and Osteoblastic Differentiation of Vascular Smooth Muscle Cells,R543.5
  12. Study on Taurine Production Monitoring and Its Quality by HPLC,TQ463
  13. Synthesis and taurine gossypol anti-tumor effect of,R965
  14. Study of the Effect of Taurine with Magnesium on SD Rats Following with Acute Severe Traumatic Brain Injury,R651.1
  15. The Study of Ruthenium Nanoclusters Coated on the Layered Materials and Its Catalytic Properties,TB383.1
  16. Study on Preparation and Quality of Taurine Mineral Vitamin Chewable Tablets,R944
  17. Pd - Catalyzed Synthsis of Conjugate Dienes from Alkynols and Alkenes,TQ203.2
  18. Synthesis of Polysubstituded Indenes Via Iron-Catalyzed Intramolecular Friedel-Crafts Cyclization,O621.25
  19. Study on the Industrialization and Extended Application of the Ethanol Production by Sweet Sorghum Stems,TS262.2
  20. Preparation and Characterization of Thiol-PVA and Its Application to the DGT,X703.1
  21. Effect of Methane Fermentation on the Technque of Alcohol Fermentation Couple with Methane Fermentation,X703

CLC: > Medicine, health > Internal Medicine > Systemic disease > Poisoning and chemical damage > Alcohol poisoning
© 2012 www.DissertationTopic.Net  Mobile