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Background: Chronic Obstructive Pulmonary Disease (Chronic Obstructive Pulmonary Disease, COPD) is a complex disease, its pathogenesis is not yet fully understood, cause of COPD risk factors including individual susceptibility factors, and environmental factors, both with each other impact. To this end, we have COPD patients D8S1179, D21S11, D7S820, CSF1PO, D3S1358, D5S818, D13S317, D16S539, D2S1338, D19S433, the VWA, D12S391, D18S51, D6S1043 and FGA fifteen short tandem repeat sequences (Short Tandem Repeat, STR) genetic polymorphism analysis to investigate the susceptibility gene regions associated with COPD incidence. And high sensitivity C-reactive protein (hsCRP), immunoglobulin G, A and M (IgG, IgA, IgM) immune indicators, blood sugar (Bs), Qing protein (ALB), creatinine (Cr), triglycerides ( TG), high density lipoprotein (HDL-C), low-density lipoprotein cholesterol (LDL-C) and other biochemical markers and white blood cells (WBC), neutrophils (NEUT #), lymphocytes (LYMPH #), red blood cell (RBC ), hemoglobin (HGB), platelet (PLT) and other routine blood indicators were detected, and to explore the association between them associated with the disease and this article relates to the 15 STR and experimental index. Methods: COPD cases provided by the Affiliated Hospital of Chifeng College, a total of 32 cases, the STR the detector control group population 100 cases, test indicators detect the control group the crowd 30 patients in the control group samples from local health crowd. Composite amplified using PCR-STR detect STR, the automatic special protein analyzer hsCRP, IgG, IgA, IgM, Hitachi 7180 automatic biochemical analyzer the Bs, ALB, Cr, TG, and HDL-C, LDL- C, automatic hematology analyzer WBC, LYMPH #, NEUT #, RBC, HGB, PLT. Results: 1 STR test results: the COPD group D7S820-9 detection rate was 12.5% ??in the control group, the detection rate of 5.0% (P = 0.038); 9.4% of the COPD group D3S1358-18 detection rate, control group, the detection rate of 3.0% (P = 0.033); the COPD group D6S1043-17 detection rate of 9.4% in the control group, the detection rate of 2.0% (P = 0.007); detection of the COPD group D18S51-19 was 9.4% in the control group, the detection rate of 2.0% (P = 0.007) that the allelic detection rate between the two groups was not statistically significant difference (P gt; 0.05). 2, COPD group compared with the control group, hsCRP levels were significantly increased, the difference was statistically significant (P <0.05), IgG levels were lower, the difference was statistically significant (P <0.05). Reduce the level of IgA IgM levels COPD group compared with the control group, but no statistically significant difference (P gt; 0.05). 3, COPD group compared with the control group ALB level and Cr water average significantly reduced, and the difference was statistically significant (P <0.05). Bs, TG, HDL-C, LDL-C level of the two groups was not statistically significant difference (P gt; 0.05). 4, COPD group compared to the control group, the level of WBC and NEUT # level significantly increased, the differences were statistically significant (P (0.05) the LYMPH the # levels were significantly lower, the difference was statistically significance (P (0.05) RBC HGB, PLT levels There was no statistically significant difference (P gt; 0.05) 5 in each experimental indicators significantly associated with certain gene loci, was statistically significant (P <0.05) Conclusion: 1.D7S820-9 D3S1358-18, D6S1043-17, D18S51-19 four loci significantly associated with COPD, and the frequency of the gene locus was significantly higher in the COPD group, suggesting that there may be in these four points near COPD susceptibility genes. 2.COPD patients with liver function, renal function, blood, immune function have varying degrees of change. experimental indicators associated with certain gene loci, suggesting large individual differences may be associated with genetic.
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