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The Clinical Research of Carotid Arterial Structure and Function in Patients with Systemic Lupus Erythematosus by Echo-tracking Technique

Author: GuoYanQin
Tutor: LeiChengGong
School: Shanxi Medical
Course: Medical Imaging and Nuclear Medicine
Keywords: Color Doppler ultrasound ETRACKING Systemic Lupus Erythematosus Carotid Structure Flexible Function
CLC: R445.1
Type: Master's thesis
Year: 2010
Downloads: 52
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Abstract

Background: Systemic lupus erythematosus (systemic lupus erythematosus. SLE) is a clinically affects multiple organ systems of the more common autoimmune diseases. Cardiovascular disease is the most common complication of SLE patients with late course of the disease and the most important cause of death. The study confirmed that atherosclerotic cardiovascular disease is the most common pathological basis, so early detection of atherosclerotic disease, subclinical disease is very important. Objective: color Doppler ultrasound detection of SLE patients with carotid IMT and blood flow parameters observed in patients with SLE carotid morphological changes characteristic; application eTRACKING, quantitative detection of SLE patients with carotid artery elasticity in change, and to explore the technology in the early diagnosis of SLE atherosclerosis aspects of clinical value. Materials and Methods: (1) select the hospitalization of 50 patients from March 2009 to November 2009 Shanxi Medical University Second Hospital rheumatology diagnosis of SLE, to meet the 1997 American College of Rheumatology diagnostic criteria for SLE diagnosis, rule out a history of angina, myocardial infarction and in patients with cerebral vascular accident. Based on the course is divided into SLE1 group (≤ 1 year) history and SLE2 group (history gt; 1) SLE1 group of 25 patients, 24 females, 1 male, age 12-48 years old, with an average (30.56 ± 10.33) years old, duration of 10 days-1 year, average (2.0 ± 4.0) months; SLE2 group of 25 patients, 24 females and 1 male, age 18 to 55 years, with an average (32.20 ± 9.64) years, duration of more than 1 year to 25 years, average (6.0 ± 11.5) years. Normal control group of 25 patients, 24 females, 1 male, aged 12-55 years, average (33.68 ± 11.39) years of age, physical examination and biochemical tests were normal healthy people. (2) blood pressure measurement: subjects resting supine bit desktop blood pressure monitor in the right upper limb blood pressure three times, each measurement interval for 10 min, 3 times the average blood pressure. Carotid ultrasound detection: application with ET technology and built-in digital image management system (e-DMS) ALOKAα10 color Doppler ultrasonic diagnostic apparatus, the probe frequency 7.5-13.0MHz connected synchronous ECG. (1) the application of the ordinary color Doppler ultrasound detection of carotid artery structure and blood flow parameters, measurement times average. (2) ET mode, capture a clear two-dimensional image, select from the carotid artery bifurcation proximal end of 2.0cm as the sampling area, adjust the M-type sampling line, perpendicular to the wall of the carotid artery in order to get the best image and maximum vessel diameter. Carotid systolic, diastolic vascular anterior and posterior wall of the trajectory in the B / M mode, real-time tracking and recording, automatic calculation of vessel diameter changes of the cardiac cycle, and access to more than 12 consecutive cardiac cycles curve artery diameter curve and save. Enter the systolic and diastolic blood pressure, the select 5-8 cardiac cycles satisfaction images enter the e-DMS online or offline analysis All data were measured three times and averaged. Images and data stored in the hard disk and CD-ROM form. Ultrasonic testing is completed by a senior physician. Statistical analysis: application SPSS13.0 statistical package was used for statistical analysis. Results: 1 color Doppler ultrasound results: three groups of carotid artery systolic and diastolic diameter was no significant difference (P> 0.05). SLE1 and control groups showed no significant difference (P> 0.05) IMT, SLE2 group and the normal group, SLE1 IMT significant difference (P lt; 0.01) Among the three groups carotid artery PSV, MDV and RI of comparison, the control group and the the SLE1 group SLE2 group there was a significant difference (P <0.01), the SLE1 group and SLE2 groups showed no significant difference (P> 0.05). 2 blood vessels echo tracking technology inspection results: three groups of carotid artery elasticity index comparison, the performance of AI no significant difference for each group, the SLE1 group, SLE2 group compared with the control group Ep - the beta for PWVβ index increased AC index decreases; the SLE2 group comparing the SLE1 group Ep -, beta PWVβ index increased AC index decreased. Conclusion: ET can be diagnosed early atherosclerosis and quantitative, to provide the basis for the early diagnosis of SLE complications of cardiovascular disease, with a high clinical value.

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