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Purposes: traditional Chinese medicine treatment of Alzheimer randomized controlled clinical trial literature to evaluate the quality of the analysis of traditional Chinese medicine treatment of Alzheimer's clinical research studies the problems of the status quo as well as the research methods and literature writing, to improve the class level of clinical research and documentation quality reference; TCM syndrome types of traditional Chinese medicine treatment of senile dementia, therapy and drug law summarized and analyzed, provide reference for Chinese medicine treatment of Alzheimer's dialectical theory of governance. Methods: A randomized controlled clinical trial literature the search term CrossSearch, supplemented by literature retrospective literature links added, published 1999-2009 in CNKI and PubMed online herbal compound to treat Alzheimer electronic retrieval. According to evidence-based medicine and clinical epidemiology, evaluation methods, and combined with the characteristics of Chinese medicine, literature Jadad score and design quality evaluation form, and to evaluate the quality of the literature. Frequency of use statistics to summarize TCM syndromes, therapy and medication. Using Microsoft Office Excel 2007 statistical data. Results: 1 Quality assessment of Jadad score of 128 RCT literature, the results show that the Jadad score ≥ 3 points of high-quality literature, a total of 19, accounting for 15% of the total number of RCT literature. 45 Jadad score ≥ 2 points of quality analysis of the literature shows that traditional Chinese medicine treatment of Alzheimer RCT literature the following problems: (1) The literature does not provide random method: only 25% of the RCT literature provides a random method. Most of the literature no hidden random program description; (2) there is no double-blind method and specific description of the blinding: only 11% of the literature double-blind method; blinded for only 9% of the literature described; (3) the lack of recorded off or removed cases: only 7% of the literature on the shedding or excluded cases were recorded; (4) no uniform diagnostic criteria, diagnostic criteria commonly used 11 kinds of internationally recognized standards as . Diagnostic criteria included in the standard writing is not standardized; (5) Clinical evaluation standards are not unified, 8 efficacy evaluation; (6) the lack of description of the type of traditional Chinese medicine diagnosis and TCM Jadad score ≥ 2 points in the literature, TCM diagnosis only 49% of the study, 29% of the literature description of the type of TCM. TCM diagnostic criteria and TCM syndromes evaluation standards are not uniform. (7) the small sample size, lack of sample size estimates, only 20% of the number of cases is greater than 100 large samples; (8) the lack of a safety evaluation: only 51% of the literature on adverse reactions described; (9) the vast majority of the literature did not follow-up report; (10) Chinese medicine prescription provided incomplete. 2 TCM syndromes, therapy and medication analysis summary Jadad score ≥ 2 points, the AD literature the number of only five and not all TCM prescription, this article only 34 VD literature: (1) TCM type: sea ??of ??marrow (liver and kidney loss) of phlegm blocking awakened and blood stasis is most common in patients with VD three TCM syndromes; healing method (2): Bushentianjing blood stasis, phlegm resuscitation TCM treatment method of VD major. VD common TCM syndromes consistent; (3) medication: 10 before use frequency of Chinese medicine the Shichangpu, Chuanxiong, Polygonum multiflorum, astragalus, wolfberry, red sage root, ginseng, angelica, Polygala, leeches and Dilong. Conclusion: The traditional Chinese medicine treatment of Alzheimer's literature to VD literature up to the highest quality. Compared with the clinical trial standards, documentation quality is still a wide gap between the lack of a multi-center, a large sample of clinical trials, research methods most RcT research and literature written quality needs to be improved. Chinese medicine treatment of VD Bushentianjing, blood circulation, phlegm resuscitation and other governance law, the use of Chinese medicine, resuscitation, blood, kidney, qi and soothe the nerves class, before the frequency of use of 10 traditional Chinese medicine for Shichangpu, Chuanxiong fleece-flower root, astragalus, wolfberry, red sage root, ginseng, angelica, Polygala, leeches and Dilong. These results provide a reference for the Chinese medicine treatment to further explore the efficacy and mechanism of Alzheimer.
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