Dissertation > Excellent graduate degree dissertation topics show

Research on Prediction of Protein-Protein Interactions Based Maximum Entropy Clustering Algorithm

Author: HeRenGao
Tutor: RenShiJun
School: Harbin Institute of Technology
Course: Computer Science and Technology
Keywords: protein interaction prediction maximum entropy clustering
CLC: Q51
Type: Master's thesis
Year: 2010
Downloads: 22
Quote: 0
Read: Download Dissertation

Abstract


All biological processes within cells invo1ve protein-protein interactions, meanwhile, the disorder of these interactions cause people sick, so analysing the interactions among proteins is not only important to uncover the mystery of the biological processes but also play an important role both in understanding the mechanisms of the diseases and the development of drugs.In the early research, people analyse protein-protein interactions mainly by experiments for the lack of data. However, these experiments are expensive and boring, people begin to analyse the protein-protein interactions by computation method as the increasing of the data, they analyse the feature of the interacting proteins and the noninteracting proteins, and then predict the interactions of proteins. Furthermore, people develop many algorithms, such as method based on random decision forest framework, method based on support vector machine, method based on Bayes and so on.The domain is the unit of structure and function of the proteins, they are a segment of conservative amino acid sequence and also an important structure and functional area for protein-protein interactions. Proteins interact with each other by special binding, and the binding site is precisely the domain, so, it is popular to think that the interactions among domains cause the interactions among proteins.In this paper, we analyse the feature of the interacting and noninteracting protein pairs, and present a method based on maximum entropy clustering algorithm to analyse and predict the protein-protein interactions. We test our method using the data in von Mering data set and the DIP database, the specificity is 94% and the sensitivity is 92%. Based the above method, we build a website (http://219.217.238.183:7001/prepi/index.jsp) to predict the interaction between proteins pairs.

Related Dissertations

  1. Research on Combinatorial Regulation of Multiple Transcription Factors,Q78
  2. Research on Graph-Based Algorithm for Tagsnps Selection,Q78
  3. Recovery Whey Soy Protein by Microfiltration and Development of Whey Powder,TQ936.2
  4. Study of Interaction between Epoxy Molecules and Carbon Fiber Surface with Molecular Simulation,TB332
  5. The Brake Performance of Hydraulic Retarder and Simualtion Research on Its Application for Aircraft Arrestment,TH137.331
  6. Lifetime Prediction and Channel Wall Erosion Accelerate Test of Hall Thruster,V439.2
  7. Research on Disease Related miRNA Mining Based on Protein-Protein Interaction Network,R341
  8. Research on Domain Entity Attribute and Event Extraction Technology,TP391.1
  9. Research and Implementation of Mining Implicit User Interest,TP311.13
  10. Establishment and Update of Similar Users’ Cluster in Personalized Information Retrieval,TP391.3
  11. Research on Removal Algorithm of Shadows in Image Segmentation,TP391.41
  12. The Research of the Text Extraction Method Based on Spectral Cut,TP391.41
  13. Process Support Vector Machine and Its Application to Satellite Thermal Equilibrium Temperature Prediction,TP183
  14. Study of Oridonin on SGC-7901 Cell Proliferation by Inhibitting Cell Cycle Proteins,R285
  15. The Value of the Heart-Type Fatty Acid Binding Protein in Early Diagnosis of Acute Myocardial Infarction,R542.22
  16. Study on Deodorization Techniques of Oyster Protein Beverage,TS254.4
  17. Preliminary Study of Phosphorylation Effect on UGT1A3 Metabolism Activity Towards Drugs,R346
  18. Expression and Purification of Influenza a Virus M2 Protein and Detection of Its Antigenicity,R392
  19. The Research on Interaction in the Public Crisis of Government and the News Media in China,D630
  20. Effects of Light, Temperature and Nitrogen on the Growth of Three Kinds of Aquatic Plants,Q945
  21. Broiler Responses to Reduced-protein Diets Suppleme Nted with Synthetic Amino Acids and Small Peptides,S831.5

CLC: > Biological Sciences > Biochemistry > Protein
© 2012 www.DissertationTopic.Net  Mobile