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The Study on Preparation and Quality of the Effervescent Tablets of Compound Recipe of Florfenicol and the Research in Pharmacodynamics of Heal the Infectious Serositis in Duckling

Author: ZhouZuo
Tutor: LiYingLun
School: Sichuan Agricultural University
Course: Basic Veterinary Science
Keywords: Florfenicol Rifampicin Duck infectious serositis Effervescent Pharmacodynamic
CLC: S859
Type: Master's thesis
Year: 2008
Downloads: 181
Quote: 1
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Abstract


Objective: duck infectious serositis (Riemerella anatipestifer) , also known as new duck disease or the duck septicemia . Disease caused by the Riemerella Anatipestifer Ducklings an acute or chronic septic disease , morbidity and mortality rates are high , against the duck industry , one of the major infectious diseases ; florfenicol To explore rifampicin combination of the test the feasibility of the treatment of infectious serositis of ducks , the the florfenicol rifampicin combination of developed and carried out according to of florfenicol rifampicin associated physical and chemical properties , in order to the ideas and methods of the combination of an antibiotic for the treatment of infectious serositis of ducks . Methods : ( 1 ) to acid , alkali tablets prepared separately from the legal system prepared florfenicol and to rifampicin joint effervescent ; (2 ) of 15 -day-old ducklings artificially induced infection Riemerella pathological model of Anatipestifer in and the florfenicol effervescent tablets and rifampin joint pharmacodynamic study . Results: (1 ) citric acid as the acid source , sodium bicarbonate as an alkali source , water-soluble starch as a binder , PEG6000 as a lubricant prepared joint effervescent , and traits , weight variation , acidity stability and The disintegration time were detected , in line with the effervescent quality requirements . ( 2) Florfenicol and rifampicin joint effervescent tablets treatment , the Bordetella clinical symptoms of the disease control the ducklings Riemerella silent , a significant reduction in morbidity and mortality . , Lactate dehydrogenase , and alanine aminotransferase were significantly reduced compared with pathological control group . (3) changes in serum enzymes in the blood biochemical parameters most obvious of lactate dehydrogenase (LDH) was significantly higher (P <0.01) and the onset of the peak period (3d) , alanine aminotransferase (ALT) was significantly higher (P <0.01 ). Joint effervescent Florfenicol with rifampicin - based drug treatment can effectively control the incidence of death , compared with pathological control group , lactate dehydrogenase , alanine aminotransferase indicators significantly reduced with healthy controls group , no significant change in pathological autopsy . Conclusion: ( 1 ) to acid , alkali tablets prepared separately prepared fluorophenyl of florfenicol and rifampicin United effervescent tablet technology is simple , stable quality . ( 2) serological markers , florfenicol combination with rifampin on the duck infectious serositis treatment effect , indeed .

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CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Animal Medicine ( Veterinary Medicine) > Veterinary Pharmacology
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