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Relationship between the Expression of Id-1, PTEN and Angiogenesis and Prognosis in ESCC

Author: LiZhiXiong
Tutor: LinJieCheng
School: Fujian Medical
Course: Oncology
Keywords: esophageal carcinoma Id-1 PTEN protein CD34 immunohistochemistry angiogenesis prognosis
CLC: R735.1
Type: Master's thesis
Year: 2008
Downloads: 53
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Abstract


Objective: To study the expressions of Id-1、PTEN protein in esophageal squamous cell carcinoma (ESCC)and their functions in ESCC angiogenesis and prognosis.Methods: ESCC 131 surgical specimens, 40 paraneoplastic esophageal noncancerous tissues (the distance to cancer border>5cm) was normal control group. The expression of Id-1、PTEN was detected by immunohistochemical method. The relationship of Id-1、PTEN and MVD was analyzed after assaying the density of microvessel (MVD) in ESCC depending on CD-34 while the relationship with prognosis was analyzed by Kaplan-Meier life table method.Results:1. The positive expression rate of Id-1 was 83.2% (109/131) in ESCC and 5% (2/40) in the incisal edge of normal tissues that showed a significant deviation (P<0.01) between them.2. The expression of Id-1 was not related to the ages、sex、infiltration degrees of patients and whether there was lymphatic metastasis or not (P>0.05), it was positively correlated with the degree of cancer differentiation and MVD (P<0.01), was negatively correlated with the prognosis of patients.3. The positive expression rate of PTEN was 62.6% (82/131) in ESCC and 97.5% (39/40) in the incisal edge of normal tissues that showed a significant deviation (P<0.01) between them.4. The expression of PTEN was not related to the ages、sex、the degree of cancer differentiation of patients (P>0.05), but it was negatively correlated with infiltration degrees、MVD and whether there was lymphatic metastasis or not (P<0.05) ,and was positively correlated with the prognosis of ESCC.5. The expression of Id-1 was negatively correlated with the expression of PTEN in ESCC,Refer to the affection of angiogenesis in ESCC, maybe Id-1 played more important role than PTEN played(P<0.05).COX regression model showed Id-1、PTEN and infiltration degrees were all important factors that may predict the prognosis of ESCC.Conclusion:1. The expression of Id-1 in ESCC tissues was higher than that in incisal edge of normal tissues,which may indicate that the higher expression of Id-1 is linked with the growth of ESCC.2. It was suggested that the high expression of Id-1 might acts as a crucial effect in promoting the angiogenesis of ESCC. The higher expression of Id-1 has worse prognosis.3. There was a down-regulated expression of PTEN in ESCC compared to the expression in incisal edge of normal tissues, which may indicate that down-regulated expression of PTEN is linked with the growth of ESCC.4. It was suggested that the down-regulated expression of PTEN might participate the angiogenesis of ESCC. The higher expression of PTEN has better prognosis.5. Refer to the affection of angiogenesis in ESCC,the expression of Id-1 ,PTEN antagonistic each other, maybe Id-1 played a more important role.6. Both Id-1 and PTEN are an independent factor that may predict the prognosis of ESCC,and it may be helpful in judging the prognosis of patients.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Esophageal tumors
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