Dissertation > Excellent graduate degree dissertation topics show

Sonographic Appearance of Metastatic Cervical Lymph Nodes from NPC and Predicting Short-term Effect of Chemoradiotherapy of These Malignant Nodes by Ultrasonography

Author: FuYiMei
Tutor: LiaoJinTang
School: Central South University
Course: Medical Imaging and Nuclear Medicine
Keywords: nasopharyngeal carcinoma metastatic cervical lymph nodes ultrasonography color Doppler flow imaging short-term effect of chemoradiotherapy
CLC: R739.63
Type: Master's thesis
Year: 2008
Downloads: 60
Quote: 0
Read: Download Dissertation

Abstract


Objective:1.To decect the characteristic of metastatic cervical lymph nodes from nasopharyngeal carcinoma(NPC)by ultrasonography and color Doppler flow imaging.2.To observe the changes of these malignant nodes follow-up during therapy period,and to investigate the value of ultrasonography in predicting short-term effect of chemoradiotherapy of metastatic cervical lymph nodes from NPC.Method:36 patients confirmed as nesopharyngeal poorly differentiated squamous-cell carcinoma pathologically by biopsy were included,and their 69 metastatic cervical lymph nodes were studied by tow-dimensional ultrasonography and color Doppler flow imaging with a 5-12 MHz high-resolution linear transducer(Philips iU 22,Netherlands). The characteristic of malignant nodes,such as position,shape,size, long/short axis ratio(L/S),inner echo,vascular distribution,blood supply grading,peak systolic velocity(PS)and resistivity index(RI),were recorded before treatment.In 25 patients,all of whom underwent chemoradiotherapy,their 43 lymph nodes were examined repeatedly after chemotherapy and approximately every 2 weeks during radiotherapy.And these follow-up malignant nodes were divided into groups according to the size and the pattern of blood flow change respectively,then the regression rate of metastatic nodes of different groups was compared. Results:1.Before treatment,the majority of malignant nodes(61/69) from NPC were hypoechoic,round or elliptical,and the minority(8/69) with illdefined borders.The mean L/S was 1.95±0.54,and 41(59.4%)of 69 malignant nodes had an L/S less than 2.In most malignant nodes,the central echogenic hilum was absent.But displaced echogenic hilum, intranodal demarcated echogenic focus which suggested coagulation necrosis and intranodal cystic necrosis was observed in partial malignant nodes.Color Doppler flow signals were scored asⅡ～Ⅲin 57(85.5%) of 69 malignant nodes,and the malignant nodes of size-more-than 4cm group had more abundant blood supply.The mean PS was 25.3±15.4 cm/s,and the mean RI was 0.715±0.142.2.During treatment,the regression rate of short axis was bigger than that of long axis.After radiotherapy,the blood supply decreased and the mean RI was 0.440±0.272(0.711±0.142 before treatment).12(80%)of 15 malignant nodes in size-bigger-than 4cm group showed good regression, while 13(46.4%)of 28 in size-shorter-than 4cm group showed good regression.But no statistical significance was observed in regression rate of different blood flow grades.The regression rate in the blood-flow-decreasing group was bigger than that in the blood-flow-increasing group and the same-blood-supply group.Conclusion:1.On graspable sonography,metastatic cervical lymph nodes from NPC are usually hypoechoic with various apperences.On color Doppler,metastatic nodes usually show abundant blood supply and tend to have high RI and PS value.During treatment,the regression rate of short axis was bigger than that of long axis,and an increase in blood flow 2 weeks after irradiation(20Gy)was observed in partial malignant nodes,but after radiation therapy a reduction in intranodal vascularity was found in all metastatic nodes.2.These malignant nodes,in which blood flow markedly decreased 2 weeks after irradiation,has quicker regression rate.This study suggests that ultrasonography maybe have a role in the follow-up of metastatic nodes from NPC receiving chemoradiotherapy.The size and the blood flow of metastatic nodes before therapy and the changes of blood flow in the therapy period may play a role in the evaluation of nodal short-term response to chemoradiotherapy.

Related Dissertations

  1. The Value of Ultrasonic Elastography in the Diagnosis and Prognosis of Breast Lesions,R445.1
  2. Research for the Expressive Correlation of EBERs and BMI-1 in Nasopharyngeal Carcinoma,R739.63
  3. Color Doppler to Determine Perinatal Outcome of Clinical Value,R714.7
  4. Evaluation of Three-dimensional Color Doppler Flow Imaging in Classification of the Vascular Characteristics of Renal Cell Carcinoma,R737.11
  5. The Research on Mri of Contrast Agent Nanoparticles C225-USPIO Marker Targeting to the Nasopharyngeal Carcinoma Xenograft in Nude Mice,R739.63
  6. The Expression of Hexokinase Ⅱ in Nasopharyngeal Carcinoma,R739.63
  7. The E-cadherin Promoter-160 C/A Polymorphism and Nasopharyngeal Carcinoma in a Chinese Population,R739.63
  8. Assessment of Chronic Hepatitis B-Related Hepatic Fibrosis by Fibroscan Stiffness Measurement Compared with Ultrasonography,R575.2
  9. Related Risk Factors to Caries after Nasopharyngeal Carcinoma Radiotherapy,R739.63
  10. To Study the Relationship Between Expression of Annexin A5 in Nasopharyngeal Carcinoma,R739.6
  11. Study of the Expression and Significance of Twist in Nasopharyngeal Carcinoma,R739.63
  12. Comparative Study on Values of Color Doppler Ultrasonography and Computer Tomography Angiography in the Patients with Carotid Endarterectomies,R654.3
  13. The Logistic Regression Analysis of High Frequency and Color Doppler Flow Imaging in Thyroid Solitary Nodules,R445.1
  14. Quality Assurance for Hyperthermia in Cervical Lymph Node Metastasis of Nasopharyngeal Carcinoma,R739.63
  15. 临床研究 Neo-adjuvant Docetaxel and Cisplatin Followed by Concurrent Docetaxel and Cisplatin with Intensity-modulated Radiation Therapy in Treatment of Locally Advanced Recurrent Nasopharynx Cancer,R739.63
  16. Proteomics Analysis of Plasma Membrane of Nasopharyngeal Carcinoma Cell Line,R739.63
  17. Effects of Qi-Boosting Toxin-Resolving Formula on the Structure of Cellular Adhesion System in the Implanted Tumors with Human NPC Cells Among Nude Mice,R739.63
  18. The Intervening Effect of Qi-Boosting Toxin-Resolving Formula on the Structures of Cystoskeleton and the Expressive Activities of Associated Protein in Nasopharyngeal Carcinoma Cells,R739.63
  19. The Study of Blood Vessel and Tissue Injured by Anti-angiogenic Drugs Basing on Raman Spectroscopy,R730.5
  20. Expression and Significance of PI3K, mTOR, Pokemon and Ku70 in Nasopharyngeal Carcinoma,R739.63
  21. CT and MRI Analysis in Nasopharyngeal Carcinoma after Radiotherapy,R739.63

CLC: > Medicine, health > Oncology > Department of Otolaryngology tumor > Pharyngeal tumors
© 2012 www.DissertationTopic.Net  Mobile