Dissertation > Excellent graduate degree dissertation topics show

Expression of E-cadherin and α/γ Catenins and Their Relationship with the Invasiveness of Pituitary Adenoma

Author: LiuKun
Tutor: JiangYuGang
School: Central South University
Course: Neurosurgery
Keywords: E-cadherin Catenins Pituitary adenoma invasive
CLC: R736.4
Type: Master's thesis
Year: 2008
Downloads: 23
Quote: 0
Read: Download Dissertation

Abstract


Objiective Through exploring the expression of E-cadherin(E-cad),α-catenin(α-cat)andγ-catenin(γ-cat)in pituitary adenoma,To investigate the relationship between E-cadherin catenin complex(CCC) and the invasiveness of pituitary adenoma,and offers theoretical and experimental evidence for studying invasive adenoma.Methods The expession of E-cadherin catenin complex was determined by immunohistochemistry in 45 cases of human pituitary adenomas by random sampling,including invasive adenoma 27 cases, noninvasive adenoma 18 cases and the relativity of their expression with hormone-producing,pituitary apoplexy and necrosis or cystoid change, tumor diameter were analyzed.Results The invasive group had a significantly lower expression of E-cad andα-cat than that of noninvasive group(x~2=8.551,P<0.01;x ~2=7.872,P<0.01).There was no statistical significance forγ-cat expression between the invasive group and noninvasive group(x~2= 0.359,P>0.05).Moreover,The expression of E-cad was significantly lower in endocrine inactive group than that in endocrine active group(x~2 =5.020,P<0.01).The expression ofγ-cat was significantly lower in the group with apoplexy,necrosis and cystis degeneration than that in the group without apoplexy,necrosis and cystis degeneration(x~2=4.294, P<0.05).the expression of E-cad andα-cat were significantly lower in high-grade pituitary adenoma group than that in low-grade pituitary adenoma group(P<0.01).Conclusions1.E-cad andα-cat is related to invasiveness of pituitary adenoma because of the reduction expression of them.2.E-cad is lower expression in nonfunctional pituitary adenoma than functional pituitary adenoma.3.The expression ofγ-cat was significantly lower in the group with apoplexy,necrosis and cystis degeneration than that in the group without apoplexy,necrosis and cystis degeneration,which indirect indicates the reduction ofγ-cat is related to invasiveness of pituitary adenoma.4.The expression of E-cad andα-cat were significantly lower in high-grade pituitary adenoma group than that in low-grade pituitary adenoma group,which indicates E-cad andα-cat are related to invasiveness extent of pituitary adenoma.The reduction expression of E-cad,α-cat andγ-cat are related to invasiveness and clinical pathological characteristics.They have significance to evaluate the invasiveness biological behavior of pituitary adenoma,and can provide evidence for instituting reasonable therapy scheme,judgging prognosis and assessing curative effect in clinic.

Related Dissertations

  1. Research on BT Toxin Oligomer Formation Induced by Lipid Raft and the Immunodetection Explore of Cadherin,S476.1
  2. Primary Studies on Transcriptome and Population Genetics of An Invasive Weed Mikania Micrantha,S451
  3. Fitness Costs of a Disrupted Cadherin Allele Conferring Cry1Ac Resistance of Helicoverpa Armigera,S435.622.3
  4. Effect of Acupuncture and Minimally Invasive Hematoma Aspiration on Rabbit Brain Damnification in Acute Stage of Intracerebral Hemorrhage,R245
  5. The Outcome between Interlocking Minimally Invasive Percutaneous Plating and Interlocking Intramedullary Nailing in Treating with Fractures of the Lower Tibia,R687.3
  6. Minimally Invasive Locking Plate Fixation for Treatment of Pilon Fracture,R687.3
  7. The Clinic Study of Comparison between Laparoscopic with Open Colonrectal Radical Surgery,R735.3
  8. The Correlation Analysis between the Hormone Leve of Pituitary Prolactinoma and Surgical Therapeutic Effects,R736.4
  9. Two kinds of knee osteoarthritis treatment methods and Cost Analysis,R687.3
  10. Retinoic acid and matrine intervention rat hepatoma change process β-catenin, E-cadherin, MMP-7 dynamic changes,R735.7
  11. The Clinical Studies of the Combination of Treatment of MIPPO Technology and Locking Compression Plate for Intertrochanteric Fracture of Femur in Elderly Patients,R687.3
  12. The Expression and Clinical Significance of GRP78 and E-cadherin Protein in Renal Clear Cell Carcinoma,R737.11
  13. The E-cadherin Promoter-160 C/A Polymorphism and Nasopharyngeal Carcinoma in a Chinese Population,R739.63
  14. Preliminary Study of P-aPKC-ι and E-cadherin Expressed in Cholangiocarcinoma and Its Significance,R735.8
  15. Minimally invasive surgical robotic systems development master manipulator,TP242
  16. Expression and Significance of E-cadherin in Retinoblastoma,R739.7
  17. β-catenin and E-cadherin in the Expression of Epithelial Ovarian Tumor and Clinical Significance,R737.31
  18. Expression of E-cadherin and Snail Which Were Related to EMT in Thyroid Cancer and Their Clinical Significance,R736.1
  19. Study on the Expression and Signification of N-cadherin、bFGF、PCNA on the Neural Tube Defects Model in Golden Hamster Induced by Hyperthermia,R363
  20. The Molecular Adjuvant C3d3 Improves the Anti-fertility Potential of Lactobacilli Lb.h CGβ-C3D3 Vaccination Via Up-regulating the CCL25-mediated Lymphocyte Homing into Genital Tract,R392
  21. The Expression and Significance of CD1a and E-cadherin in Cervical Intraepithelial Neplasia and Quamous Cell Carcinomas of the Cervix,R737.33

CLC: > Medicine, health > Oncology > Internal endocrine tumors > Pituitary tumor
© 2012 www.DissertationTopic.Net  Mobile