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Objective To investigate the anti-glomerular basement membrane (GBM) antibody different clinical forms of the disease and the clinical and pathological features , in order to deepen the understanding of the group of diseases , to improve early diagnosis and cure rate . Detected in our department for the past five years 22 cases of anti-GBM antibody disease clinical and pathological data were retrospectively analyzed . Results of 1.22 patients with clinical manifestations of varying severity , 21 cases showed acute nephritic syndrome with rapidly progressive renal failure , progressive anemia , one cases of patients with normal renal function , 8 cases with pulmonary hemorrhage . 2.11/22 (50% ) patients with anti-GBM antibodies alone , 7 / 22 cases (32 %) of anti-GBM antibodies associated with anti - neutrophil cytoplasmic antibody (ANCA) positive , 4 / 22 cases (18%) anti- GBM antibodies associated with positive antinuclear antibodies (ANA) , 1/4 of which were accompanied by anti- double-stranded DNA (ds-DNA) antibodies , the other 1/4 cases of anti- ds-DNA antibodies , anti-Sm antibodies both positive . Associated with ANCA -positive group compared with the other two groups , the age of onset of anti-GBM antibody levels lower , but not statistically significant , the treatment efficiency is also no significant difference . 3.13/22 patients, renal biopsy , 11 / 13 cases crescentic glomerulonephritis , 6 / 11 patients, more than 85% of glomerular involvement , 1 / 13 cases of chronic sclerosing glomerulonephritis , 1 /13 mild mesangial proliferative glomerulonephritis . 13 patients immunofluorescence was no typical Ig, C3 deposition along the glomerular capillary wall line . 8 cases of immunofluorescence along mesangial area and capillary wall granular distribution of three cases of immunofluorescence negative . Immunosuppressive therapy , the complete remission group, improved anti-GBM antibody levels in the group and the ineffective group of patients diagnosed no significant difference . Conclusion 1. Clinical manifestations of anti-GBM disease of varying severity , the small number of patients with normal renal function or damage lighter . Minority patients with ANA, anti - ds-DNA antibodies , anti-Sm antibodies , suggesting that some patients with lupus nephritis may have anti-GBM antibodies . 3. Kidney Immunopathological is not performed for typical IgG and C3 along glomerular capillary loops line like deposition , some patients showed granular deposition . Prognosis and outcome of anti-GBM antibody disease may be associated with serum anti-GBM antibody levels no correlation , early diagnosis , timely intensive immunosuppressive treatment is essential to improve the prognosis of patients .
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