Dissertation > Excellent graduate degree dissertation topics show

The Effect of Leptin in Rats with Brain Injury and Femoral Fracture

Author: WangLei
Tutor: CaoXiaoJian；WeiYongZhong
School: Nanjing Medical University
Course: Orthopaedic Surgery
Keywords: leptin braininjury femoral fracture callus formation
CLC: R683.42
Type: Master's thesis
Year: 2008
Downloads: 61
Quote: 0
Read: Download Dissertation

Abstract


objective:To study the relationship between leptin and enhanced osteogenesis after brain injury by investigating the expression of leptin in callus and the level of leptin in serum of rats with brain injury and femoral fracture.Methods:64 male SD rats were randomly divided into 4 groups: normal control,brain injury group,fracture group,fracture with brain injury group(n=16 per group).Fracture and brain injury models were established.The rats were sacrificed 2、4、8and12weeks respectively after operation,and then the leptin concentration in serum was detected by rat leptin RIT kit and the callus was observed in the X-ray film and volume was measured. The callus was also examed with immunohistochemical staining.Results:The serum levels of leptin in the brain injury group,fracture group or fracture with brain injury group significantly increased as compared with that in control group at the 2nd week after operation(P＜0.05),The concentration of the leptin in serum of the fracture with brain injury group was higher than that of brain injury or fracture group 4、8weeks after operation(P＜0.05)and declined from 8rd week;at the 12 rd week after operation the difference in above four groups was not statistically significant.(P＞0.05).The mean percentage of positive cells in callus of the fracture with brain injury group was higher than that of the fracture group(P＜0.05).Callus formation of the fracture with brain injury group were larger and formed more quickly than those of the fracture group(P＜0.05).Conclusion:The femoral fracture recovers rapidly and leptin in the callus expresses highly in fracture with brain injury group,which suggests that leptin could yield the healing of the fracture.

Related Dissertations

  1. Effect of in Ovo Leptin Administration on Hepatic Expression of Genes and Micrornas Involved in Cholesterol Metabolism in Broiler Chickens,S831
  2. Effect of Maternal Dietary Protein Level on Fat Deposition in the Piglets at Weaning and the Research of Lipid Metabolism Regulation Mediated by Leptin,S828
  3. Effect of in Ovo Leptin Administration on Posthatch Skeletal Muscle Growth in Broiler Chickens,S831
  4. A Clinical Comparative Study of Dynamic Condylar Screw、Locking Plate to Treat in Distal Femoral Fractures,R687.3
  5. Effects of Acidic Fibroblast Growth Factor Fragments on Nocturnal Feeding in Rats by Intracerebroventricular,R346
  6. The Discussion of Mechanism That Leptin Promotes Cell Proliferation of Human Prostate Adenocarcinoma,R737.25
  7. Role of Leptin in the Mouse Myocardial Ischemia-Reperfusion Injury,R363
  8. Effect of Ea on Expression of Leptin、leptin Receptor Mrna in Hypothalamus Anddiponectin in Rats with NAFLD,R245
  9. Expressions of Leptin and Lipoprotein (a) in Esophageal Squamous Cell Carcinoma and Their Clinical Significance,R735.1
  10. Development and Biomechanical Study of Distal Femoral Sub-Condyle Plate,R687.3
  11. A Clinical Retrospective Analysis of the Treatment of Intertrochanteric Femoral Fracture by PFN, Anatomy-special Plate and DHS,R687.3
  12. Effects of Active Components in Pinellia Heart-Draining Decoction on Leptin and Endothelin-1 in Rat with Gastric Ulcer,R285.5
  13. The Research of Leptin on Insulin Receptor and Insulin Receptor Substrate-1 in Early Pregnancy Trophoblast Cells,R714.256
  14. The Relationship betwneen Leptin and the Type 2 Diabetes with Coronary Heart Disease and the Effects of Hypoglycemic Drugs on the Leptin Level in Plasma,R541.4
  15. The Effect of Different Feeding Patterns in the Early Life on Ghrelin and Leptin in Adult Rats,R723.14
  16. OB-R_b gene in sheep HPG axis positioning and expression of negative energy balance law,S826
  17. Nutritional intervention moxibustion obese rats experimental study of leptin and insulin,R246.1
  18. The Influence of Fuzhengxiezhuobaoshen Decoction on LP, Renal Function and Renal Pathological Change in 5/6 Nephrectomized CRF Rats,R285.5
  19. The Appraisal and Study on Anti-obesity Efficacy of Puerh Tea,R285
  20. Leptin, leptin receptor gene variants associated with type 2 diabetes Correlation of bone metabolism,R587.1
  21. Inhibition of Leptin-induced Endothelin-1 Expression by Atorvastatin Through Extracellular Signal-regulated Kinase Signaling Pathway in Vascular Smooth Muscle Cells,R965

CLC: > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Fracture,bone damage > Limb fractures > Lower extremity fractures
© 2012 www.DissertationTopic.Net  Mobile