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Objective: To analyze the risk factors of infant and child cardiopulmonary bypass acute kidney injury (the Acute KidneyInjury, AKI). Methods: October 2003 to September 2007, the Second Xiangya Hospital of Thoracic Surgery cardiopulmonary bypass in infants and children were 3800 cases, according to the latest ADQI acute kidney injury (AcuteKidney Injury AKI) diagnostic criteria, patients were divided into Group A of AKI (AKI group) and group B (control group) did not occur AKI A group of AKI (AKI group) 266 cases of patients with B group (control group) did not happen 3534 cases of AKI, all variables single factor chi-square test, multivariate logistic regression analysis or the Mann-Whitney U test. Results: infant cardiac surgery, cardiopulmonary bypass complicated by AKI overall incidence rate of 7%, univariate analysis to compare results suggest that age group A (AKI group) and group B (control group) (p = 0.047), preoperative serum creatinine level ( p <0.001), ejection fraction (p <0.001), beta 2-micro-globulin (P = 0.003), serum albumin level (p <0.001), serum uric acid levels (p <0.001); the intraoperative pulmonary bypass time (p <0.001), the main artery occlusion (P <0.001) and mannitol use (p <0.001); postoperative intubation time (p <0.001), hypotension (p <0.001), oxygen partial pressure (p <0.001) and PH value (p <0.001) and the occurrence of AKI risk was statistically significant. Multivariate analysis layer screening: A group (AKI group) and group B (control group) results showed that preoperative creatinine levels (p <0.000), left ventricular ejection fraction (p <0.000), serum uric acid levels (p = 0.015), blood beta2-microglobulin (p = 0.002); the intraoperative pulmonary bypass time (p <0.000), the main artery occlusion (p <0.000), mannitol (P = 0.041); postoperative intubation time (p <0.000), hypotension (p = 0.027) and oxygen partial pressure (p <0.000) were statistically significant, suggesting that may be an independent risk factor for AKI. Conclusion: age, preoperative creatinine levels, ejection fraction, heart failure, beta 2-micro-globulin, albumin, blood uric acid level; intraoperative pulmonary bypass time, aortic clamping time, the use of mannitol; postoperative intubation time, hypotension, and PH value, the oxygen partial pressure is AKI related factors, age, preoperative creatinine levels, ejection fraction, beta 2-micro-globulin, serum uric acid levels, intraoperative pulmonary bypass time, aortic blocking time and mannitol, postoperative intubation time, blood pressure, oxygen partial pressure are independent risk factors for AKI occurred.
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