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Purpose : by measuring heart beating surgery group with cardiac arrest surgery patients peripheral venous blood T lymphocyte subsets (CD3 ~, CD4 ~, CD8 ~, CD4 ~ / CD8 ~) to share peripheral blood mononuclear cells percentage and concentration of immunoglobulin (IgG, IgA, IgM) , the evaluation of cardiac beating heart surgery on immune function . Methods: 30 patients with cardiopulmonary bypass cardiac surgery of congenital heart disease with ventricular septal defect ( defect diameter lt; 0.5cm) or atrial septal defect patients . 15 cases were randomly divided into two groups, the beating heart group to implement mild hypothermia heart beating open heart surgery , the cardiac arrest group of 15 patients conventional hypothermic cardiopulmonary bypass in cardiac arrest the heart during open heart surgery . Determination of the two groups of patients before and after surgery 1d postoperative 3d postoperative 7d each time peripheral venous blood T lymphocyte subsets (CD3 ~, CD4 ~, CD8 ~) in peripheral blood mononuclear cells percentage occupied , CD4 ~~ / CD8 ~ ratio and IgG , IgA in the IgM concentration . Results: 1. Preoperative two sets of CD3 to , CD4 ~ , CD8 ~~ , CD4 ~~ / CD8 ~~ and IgG , IgA, IgM value of comparison were normal , with no significant difference ( P gt ; 0.05 ) . 2 patients with abnormal CD3 to CD4 ~~, CD4 - / CD8 significantly reduced, postoperative the 1d achieve the lowest ( P lt; 0.01 ) ; minimize IgG , IgA, and IgM postoperative 3d ( P lt; 0.01 ) CD8 ~ was significantly higher (P lt; 0.01), both after 7d basic recovery . 3 . Beating group CD3 to CD4 ~~, IgG , IgA , IgM postoperative 1d, 3d was significantly higher (P lt; 0.05 or P lt ; 0.01 ) , CD4 ~~ / CD8 postoperative 1d higher than the arrest group (P lt; 0.05) and CD8 ~ than arrest group had no significant difference ( P gt ; 0.05) . Conclusion : The beating heart cardiac surgery compared with cardiac arrest heart surgery can significantly reduce cardiopulmonary bypass on immune function adverse effects .
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