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The optical axis limonene leaves蒟, also known eighteen disease , the crooked Ye Zailan , small Ma pimple , colon wind is the Piperaceae pepper genus , expelling wind and cold , Shujin , Xiaoyusan swollen , the analgesic effect of , can be used for cold stomach , dysmenorrhea , amenorrhea , rheumatic pain, bruises , mainly distributed in Yunnan , Hainan , Guangxi , Guangdong , Fujian and southern China . Firstly, an overview of the conduct of the the pepper genus chemical constituents and pharmacological screening , followed by parts of the optical axis limonene leaves蒟antidepressant activity and the study of the chemical composition of its active site , as follows : 1 . the active site of the optical axis the of limonene leaves蒟antidepressant screening study found that the ethyl acetate extract the optical axis the limonene leaves Betel antidepressant active site , its antidepressant effects of clomipramine hydrochloride , petroleum ether and water extraction None antidepressant activity. Ethanol extract of the optical axis of the the limonene leaves Betel preliminary qualitative analysis of the chemical composition , display , the optical axis limonene leaf蒟may contain alkaloids , flavonoids , steroids , phenols and tannins , excluding anthracene quinone , coumarin and terpene lactones . 3 according to the results of pharmacological experiments , for active site - ethyl acetate portion of the separation and purification of the chemical composition , the use of the solvent method , the separation and purification methods of the silica gel column chromatography , recrystallization, etc. are separated from the optical axis of the ethyl acetate extract of the the limonene leaves蒟five compounds , and their structures were identified by chemical analysis methods and modern spectroscopic techniques . These compounds are : (2E, 4E) - N - isobutyleicosadienamide ( the EA- I ) , beta - sitosterol or alcohol ( the EA- II ) 1,5 -diphenyl - Penta - 1 ,4 - dien -3 -one ( EA - Ⅲ), Cepharanone B (EA-Ⅳ), N-(2'-hydroxy-ethyl)-N-methyl-3 ,4-methylene-dioxybenzamide (EA-Ⅴ). The obtained compound ( 2E , 4E ) - N - isobutyleicosadienamide first separated from the optical axis limonene leaf蒟, N-(2'-hydroxy-ethyl)-N-methyl-3 ,4-methylenedioxybenzamide is a new compound .
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