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The Expression and Clinical Significance of Survivin and p21 in Laryngeal Squamous Cell Carcinoma

Author: LiuWanZuo
Tutor: LiShuHua
School: Dalian Medical University
Course: Otorhinolaryngology
Keywords: Survivin p21 Laryngeal squamous cell carcinoma Apoptosis
CLC: R739.65
Type: Master's thesis
Year: 2008
Downloads: 27
Quote: 0
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Abstract


Objective: To investigate Survivin provide a theoretical basis for squamous cell carcinoma of the larynx , development and correlation with p21 gene therapy for laryngeal squamous cell carcinoma . : Select laryngeal surgery paraffin specimens of 31 cases , the application of the method of immunohistochemistry to detect Survivin and p21 in laryngeal squamous cell carcinoma , paraneoplastic normal tissue , normal laryngeal tissue expression , while the experimental data obtained statistically analysis . Results : 1 in normal tissue of the throat did not see the expression of Survivin obvious expression in LSCC tissues , lymph node metastasis in poorly differentiated expression in stage Ⅲ , Ⅳ stage laryngeal carcinoma rate the improvement in cancer tissue Survivin expression also significantly higher than the normal laryngeal tissues . Lower degree of differentiation of laryngeal carcinoma Survivin expression , the stronger (P <0.05), lymph node metastasis Survivin expression was significantly higher than without lymph node metastasis ( P <0.05 ) . Expression 2.p21 cancer nests lower intensity of expression in LSCC organization , lack of positive expression in the cancer tissue , there is a certain degree of expression in normal laryngeal tissue . p21 expression in different T stage was statistically significant (P <0.05), with the expansion of the scope of the primary tumor site infiltration , the expression intensity decreases . p21 expression with tumor differentiation , tumor M stage cervical lymph node metastasis and recurrence no correlation . Conclusion : ( 1 ) of Survivin to a certain extent reflect the degree of tumor invasion . The ⑵ p21 expression and prognosis of LSCC certain degree of correlation can be used as an important indicator of the LSCC prognosis . ⑶ both in the LSCC expression was negatively correlated .

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CLC: > Medicine, health > Oncology > Department of Otolaryngology tumor > Laryngeal tumors
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