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Significance and Expression of Matrix Metalloproteinases9 Production in Cholangiocarcinoma Cell Nerval Metastasis Potential

Author: YueZhong
Tutor: ZhaoHaoLiang
School: Shanxi Medical
Course: Surgery
Keywords: cholangiocarcinoma, Metastasis Matrix metalloproteinases
CLC: R735.8
Type: Master's thesis
Year: 2008
Downloads: 14
Quote: 0
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Abstract


Objective To study the Significance of matrix metalloproteinases activity in cholangiocarcinoma cell with different lymphatic and nerval metastasis potential.Methods Sandwich enzyme-linked immunosorbent assay(ELISA) was used to detect the difference of MMP-9 product and activities in cholangiocarcinoma cell line(QBC939) that were incubated in serum-free medium,homogenate of lymph node or nerve tissue,respectively.Results After incubation in the serum-free medium,the production of MMP-9 was at the low level in QBC939(19.93±2.94).AfterQBC939 were incubated in homogenate of lymph node,nerve the expression of MMP-9 was upregulated apparently,which were(27.33±3.98),(27.16±4.11) respectively,higher than that of the serum-free medium(P＜0.001).Conclusion:Hostmicroenvironment could contribute to the increasing of MMP-9 in QBC939,which is closely correlated to their specific lymphatic nerval metastasis potential.

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