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The Study on the Relationship between PPARγ2 Gene Pro12Ala Polymorphism and Diabetes in Familial Type 2 Diabetes Mellitus of Uygur in Xinjiang

Author: XianMuSiZuo·RouZi
Tutor: XieZiJing
School: Xinjiang Medical University
Course: Internal Medicine
Keywords: Uygur familial type 2 diabetes PPARγ2 Polymorphism heritability
CLC: R587.1
Type: Master's thesis
Year: 2008
Downloads: 53
Quote: 0
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Abstract


Objective To analyse the relationship between PPARγ2 gene Pro12Ala polymorphism and diabetes in familial type 2 diabetes mellitus of Uygur in Xinjiang. Methods We chose 62 Uygur type 2 diabetic families and apply PPAP statistic software to analyse the genetic pattern. The polymorphism of PPARγ2gene Pro12Ala measured by SNP-Stream of gene chip method. SPSS13.0 statistic analysis software was used to test the relationship between PPAR-γ2 gene Pro12Ala polymorphism and the first and second degree relative in familial type 2 diabetes mellitus. Results 1)The heritability of the first degree relative in Uygur familial type 2 diabetes was 0.578 and of the second degree relative was 0.032. With the down of the degree relative, the heritability was decreased; 2)There was no significant difference in PPARγ2gene Pro12Ala polymorphism between the first and second degree relative in familial type 2 diabetes mellitus; 3)The all data including BMI、FPG、Lipid and et al) had no significant difference among three kinds of genotypes. Conclusion With the down of the degree relative, the heritability was decreased ; There was no significant difference in PPARγ2 gene Pro12Ala polymorphism between the first and second degree relative in familial type 2 diabetes mellitus.

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
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