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The Changes of Plasma Levels of Brain Natriuretic Peptide in Patients with Chronic Heart Failure

Author: PangChenZhu
Tutor: WangXiong
School: Shanxi Medical
Course: Internal Medicine
Keywords: Chronic heart failure Brain natriuretic peptide
CLC: R541.6
Type: Master's thesis
Year: 2008
Downloads: 124
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Abstract


Objective This study was performed to explore the correlation among plasma levels of brain natriuretic peptide(BNP) and the left ventricular function and structure in patients with chronic heart failure(CHF),and to evaluate the value of plasma levels of brain natriuretic petides in the CHF diagnosis.Methods The blood samples were obtained from 53 patients with congestive heart failure (CHF) and 20 patients without CHF.among patients with CHF,18 with coronary artery disease,10 with dilated cardio myopathy(DCM),11with hypertensive heart disease.14with valvular incompetence predominant rheumatic heart disease(RHD).Accoriding to the New York Heart Association(NYHA) class,15 patients were classified NYHAⅡ,21 NYHAⅢ,17 NYHAⅣ.Aged 45～83,average(67.32±8.22).Among patients with without CHF,aged 43～81,average(65.95±8.59).Plasma levels of brain natriuretic peptide(BNP) were measured by radio immuno assay.Doppler echocardiography was performed to measure left ventricular function and structure.Results BNP levels in CHF group were higher than those in non-CHF group(P＜0.01). Comparisions were made of BNP levels between different etiological groups.BNP levels were higher in coronary artery disease than those in other three etiological groups,and there was a statistical significance(P＜0.01).No difference was observed in BNP levels between other three etiological groups(P＞0.05).Comparisions were also made of BNP levels between different heart function groups,and a statistical difference was found between NYHAⅡand NYHAⅢ,and between NYHAⅡand NYHAⅣ(P all＜0.01).NYHAⅢand NYHAⅣwas compared,and no difference was statistically significant(P＞0.05).BNP plasma levels had positive correlations with different classification of heart function(P＜0.01).plasma levels of BNP had a negative correlation with LVEF(P＜0.01),BNP plasma levels had a positive correlation with LVEDD and LVESD(P all＜0.01).Conclusions BNP leves had close relationship with left ventricular structure,BNP plasma levels were good markers used to reflect left ventricular function.Measurement of BNP plasma levels were useful to reflect the immediate change of left ventricular function.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Blood circulation failure
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