|
A 1200 t / year of sodium penicillin production line is put into operation , the production process can not meet the requirements of the new equipment , new systems , resulting in crushing crystal particle size distribution of the lack of concentration , poor mobility , automatic nesting Tank \not operate properly , the product quality is unstable , preparations packing difficulties , technical indicators and the production capacity is far less than the design requirements . In this paper, the key process in the production of penicillin sodium analysis , research and production implementation . Alternative to traditional tank extraction process using centrifuge extraction process , the effects of extraction process many influencing factors , to optimize the extraction process parameters to improve the operating flexibility of different materials , and improve the quality of intermediates and yield . Identified through the of penicillin sodium crystal habit , optimized crystallization process parameters the crystallization equipment based on the transformation of the system , solve the penicillin sodium crystal habit irregular , fragile , particle size distribution is not concentrated . Verified through test filtered, washed, dried, the process of the different operating conditions with suction filtration speed , drying time, the relationship of the crystal habit , and to optimize the operation of the \poor mobility problems , to achieve the \The optimization process has been successfully applied to the production of penicillin sodium , results showed that: the implementation of this process the production of penicillin sodium crystal size distribution concentrated liquidity improved product quality remains the leading domestic level , completely adapted to the preparation packing requirements , and the first in the country to achieve a fully enclosed production of penicillin sodium sterile bulk drugs . The process of production capacity to meet and exceed the design level , technical indicators improved significantly , significant economic and social benefits .
|